PMID- 16490441 OWN - NLM STAT- MEDLINE DCOM- 20060418 LR - 20151119 IS - 0002-9149 (Print) IS - 0002-9149 (Linking) VI - 97 IP - 5 DP - 2006 Mar 1 TI - Circadian variation of endothelial function in idiopathic dilated cardiomyopathy. PG - 699-702 AB - This study measured flow-mediated dilation (FMD) of the brachial artery 3 times a day (6:30 a.m., 11:30 a.m., and 9 p.m.) in 7 normal subjects and 14 patients with idiopathic dilated cardiomyopathy (7 in New York Heart Association [NYHA] functional class I or II and 7 in NYHA functional class III or IV). FMD in normal subjects and patients in NYHA class I or II showed a circadian variation, being lowest in the morning and highest at night. Compared with them, FMD in patients in NYHA class III or IV was lower and almost constant during the day, showing loss of significant circadian variation in endothelial function in patients with congestive heart failure. FAU - Maruo, Takeshi AU - Maruo T AD - Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Okayama, Japan. FAU - Nakatani, Satoshi AU - Nakatani S FAU - Kanzaki, Hideaki AU - Kanzaki H FAU - Kakuchi, Hiroyuki AU - Kakuchi H FAU - Yamagishi, Masakazu AU - Yamagishi M FAU - Kitakaze, Masafumi AU - Kitakaze M FAU - Ohe, Tohru AU - Ohe T FAU - Miyatake, Kunio AU - Miyatake K LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20060109 PL - United States TA - Am J Cardiol JT - The American journal of cardiology JID - 0207277 RN - 0 (Biomarkers) RN - 0 (Vasodilator Agents) RN - 114471-18-0 (Natriuretic Peptide, Brain) RN - 85637-73-6 (Atrial Natriuretic Factor) RN - G59M7S0WS3 (Nitroglycerin) SB - IM MH - Adult MH - Atrial Natriuretic Factor/blood MH - Biomarkers/blood MH - Blood Flow Velocity MH - Brachial Artery/physiopathology MH - Cardiomyopathy, Dilated/drug therapy/*physiopathology MH - Case-Control Studies MH - *Circadian Rhythm/drug effects MH - Endothelium, Vascular/drug effects/*physiopathology MH - Female MH - Forearm/blood supply MH - Heart Rate MH - Humans MH - Male MH - Middle Aged MH - Natriuretic Peptide, Brain/blood MH - Nitroglycerin/therapeutic use MH - Regional Blood Flow MH - Stroke Volume MH - Treatment Outcome MH - Vasodilation/drug effects MH - Vasodilator Agents/therapeutic use EDAT- 2006/02/24 09:00 MHDA- 2006/04/19 09:00 CRDT- 2006/02/24 09:00 PHST- 2005/06/11 00:00 [received] PHST- 2005/09/09 00:00 [revised] PHST- 2005/09/09 00:00 [accepted] PHST- 2006/02/24 09:00 [pubmed] PHST- 2006/04/19 09:00 [medline] PHST- 2006/02/24 09:00 [entrez] AID - S0002-9149(05)02019-9 [pii] AID - 10.1016/j.amjcard.2005.09.118 [doi] PST - ppublish SO - Am J Cardiol. 2006 Mar 1;97(5):699-702. doi: 10.1016/j.amjcard.2005.09.118. Epub 2006 Jan 9.