PMID- 16490595
OWN - NLM
STAT- MEDLINE
DCOM- 20060516
LR  - 20071115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 165
IP  - 1
DP  - 2006 Feb
TI  - Translocation (5;10)(q22;q24) in a case of acute lymphoblastic leukemia.
PG  - 36-40
AB  - The activation of genes important to acute lymphoblastic leukemia (ALL) may be 
      evidenced by somatically acquired chromosomal translocations found recurrently in 
      different patient subgroups. It is for this reason that research efforts have 
      focused on the molecular dissection of recurring chromosomal rearrangements. 
      However, even though a large number of leukemia-causing genes have been 
      identified, the genetic basis of many ALL cases remains unknown. We and others 
      have reasoned that novel translocations found in the leukemic cells of ALL 
      patients may mark the location of more frequent gene rearrangements that are 
      otherwise hidden submicroscopically within normal or complex karyotypes. Towards 
      this end, we here describe the first reported association of a t(5;10)(q22;q24) 
      with adult ALL. Fluorescence in situ hybridization (FISH) and Southern blot 
      hybridization studies have eliminated likely involvement of the candidate genes 
      APC and MCC on chromosome 5, and PAX2, TLX1, and NFKB2 on chromosome 10. Results 
      further suggest that the breakpoint on chromosome 5 lies centromeric of APC and 
      the chromosome 10 breakpoint is centromeric of PAX2. The genomic regions 
      disrupted by this t(5;10)(q22;q24) have not previously been associated with 
      leukemia.
FAU - Gough, Sheryl M
AU  - Gough SM
AD  - Cancer Genetics Research Group, Department of Pathology, Christchurch School of 
      Medicine & Health Sciences, PO Box 4345, University of Otago, Christchurch, New 
      Zealand.
FAU - Benjes, Suzanne M
AU  - Benjes SM
FAU - McDonald, Margaret
AU  - McDonald M
FAU - Heaton, David
AU  - Heaton D
FAU - Ganly, Peter
AU  - Ganly P
FAU - Morris, Christine M
AU  - Morris CM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Bone Marrow Cells/pathology
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 10
MH  - *Chromosomes, Human, Pair 5
MH  - Humans
MH  - Male
MH  - Metaphase
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/pathology
MH  - *Translocation, Genetic
EDAT- 2006/02/24 09:00
MHDA- 2006/05/17 09:00
CRDT- 2006/02/24 09:00
PHST- 2005/04/04 00:00 [received]
PHST- 2005/07/29 00:00 [revised]
PHST- 2005/08/03 00:00 [accepted]
PHST- 2006/02/24 09:00 [pubmed]
PHST- 2006/05/17 09:00 [medline]
PHST- 2006/02/24 09:00 [entrez]
AID - S0165-4608(05)00460-7 [pii]
AID - 10.1016/j.cancergencyto.2005.08.008 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2006 Feb;165(1):36-40. doi: 
      10.1016/j.cancergencyto.2005.08.008.