PMID- 16491100
OWN - NLM
STAT- MEDLINE
DCOM- 20070104
LR  - 20181113
IS  - 0007-1188 (Print)
IS  - 1476-5381 (Electronic)
IS  - 0007-1188 (Linking)
VI  - 147
IP  - 8
DP  - 2006 Apr
TI  - Effects of MDMA, MDA and MDEA on blood pressure, heart rate, locomotor activity 
      and body temperature in the rat involve alpha-adrenoceptors.
PG  - 926-34
AB  - The effects of injection of 3,4-methylenedioxymethamphetamine (MDMA), 
      3,4-methylenedioxyamphetamine (MDA) and N-ethyl-3,4-methylenedioxyamphetamine 
      (MDEA) (all 20 mg kg(-1)) on blood pressure, heart rate, core body temperature 
      and locomotor activity in conscious rats were investigated using radiotelemetry. 
      MDMA and MDA produced a prolonged increase in both systolic and diastolic 
      pressures, with MDA causing the most marked rise. MDEA produced a transient but 
      nonsignificant fall in diastolic pressure. The pressor response produced by MDA 
      was accompanied by bradycardia. All three amphetamine derivatives caused an 
      initial hypothermic response; however, MDA also produced a subsequent 
      hyperthermia, and the speed of recovery from hypothermia was MDA>MDMA>MDEA. The 
      alpha2A-adrenoceptor antagonist 
      2-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-1H-isoindole (BRL 
      44408) (1 mg kg(-1)) prolonged the hypothermic response to MDMA. Only MDA induced 
      locomotor activity when given alone, but in the presence of BRL 44408, MDMA 
      produced increased locomotor activity. The order of potency for producing 
      isometric contractions of rat aorta (alpha1D) and vas deferens (alpha1A) was 
      MDA>MDMA>MDEA, with MDEA acting as an alpha1-adrenoceptor antagonist with a pK(B) 
      of 4.79+/-0.12 (n = 4) in aorta. The order of potency for prejunctional 
      inhibition of stimulation-evoked contractions in rat vas deferens 
      (alpha2A-adrenoceptor mediated) was MDA>MDMA>MDEA. Blood pressure actions of the 
      three amphetamine derivatives may be at least partly due to alpha1-adrenoceptor 
      agonism or antagonism. The reversal of the hypothermic actions are at least 
      partly due to alpha2A-adrenoceptor agonism since the hypothermic response was 
      more prolonged with MDEA which exhibits low alpha2A-adrenoceptor potency, and 
      effects of MDMA after alpha2A-adrenoceptor antagonism were similar to those of 
      MDEA.
FAU - Bexis, Sotiria
AU  - Bexis S
AD  - Department of Physiology, Royal College of Surgeons in Ireland, 123 St Stephen's 
      Green, Dublin 2, Ireland.
FAU - Docherty, James R
AU  - Docherty JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Imidazoles)
RN  - 0 (Indoles)
RN  - 0 (Isoindoles)
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
RN  - ZET7B198W2 (BRL 44408)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/*pharmacology
MH  - Animals
MH  - Aorta/drug effects
MH  - Blood Pressure/drug effects
MH  - Body Temperature/drug effects
MH  - Heart Rate/drug effects
MH  - Imidazoles/pharmacology
MH  - Indoles/pharmacology
MH  - Isoindoles
MH  - Male
MH  - Motor Activity/drug effects
MH  - Muscle Contraction/drug effects
MH  - Muscle, Smooth/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Adrenergic, alpha/*metabolism
MH  - Time Factors
MH  - Vas Deferens/drug effects
PMC - PMC2189797
EDAT- 2006/02/24 09:00
MHDA- 2007/01/05 09:00
PMCR- 2007/04/01
CRDT- 2006/02/24 09:00
PHST- 2006/02/24 09:00 [pubmed]
PHST- 2007/01/05 09:00 [medline]
PHST- 2006/02/24 09:00 [entrez]
PHST- 2007/04/01 00:00 [pmc-release]
AID - 0706688 [pii]
AID - 10.1038/sj.bjp.0706688 [doi]
PST - ppublish
SO  - Br J Pharmacol. 2006 Apr;147(8):926-34. doi: 10.1038/sj.bjp.0706688.