PMID- 16492931
OWN - NLM
STAT- MEDLINE
DCOM- 20060615
LR  - 20191210
IS  - 1055-9965 (Print)
IS  - 1055-9965 (Linking)
VI  - 15
IP  - 2
DP  - 2006 Feb
TI  - Molecular profiling of computed tomography screen-detected lung nodules shows 
      multiple malignant features.
PG  - 373-80
AB  - RATIONALE AND PURPOSE: Low-dose spiral computerized axial tomography (spiral CT) 
      is effective for the detection of small early lung cancers. Although published 
      data seem promising, there has been a significant degree of discussion concerning 
      the potential of overdiagnosis in the context of spiral CT-based screening. The 
      objective of the current study was to analyze the phenotypic and genetic 
      alterations in the small pulmonary malignancies resected after detection in the 
      University of Navarra/International Early Lung Cancer Action Project spiral CT 
      screening trial and to determine whether their malignant molecular features are 
      similar to those of resected lung tumors diagnosed conventionally. EXPERIMENTAL 
      DESIGN: We analyzed 17 biomarkers of lung epithelial malignancy in a series of 11 
      tumors resected at our institution during the last 4 years (1,004 high-risk 
      individuals screened), using immunohistochemistry and fluorescence in situ 
      hybridization (FISH). A parallel series of 11 gender-, stage-, and 
      histology-matched lung cancers diagnosed by other means except screening was used 
      as control. RESULTS: The molecular alterations and the frequency of phenotypic or 
      genetic aberrations were very similar when screen-detected and nonscreen-detected 
      lung cancers were compared. Furthermore, most of the alterations found in the 
      screen-detected cancers from this study were concordant with what has been 
      described previously for stage I-II lung cancer. CONCLUSIONS: Small early-stage 
      lung cancers resected after detection in a spiral CT-based screening trial reveal 
      malignant molecular features similar to those found in conventionally diagnosed 
      lung cancers, suggesting that the screen-detected cancers are not overdiagnosed.
FAU - Pajares, Maria J
AU  - Pajares MJ
AD  - Oncology Division, Center for Applied Medical Research, Clinica Universitaria de 
      Navarra, Pamplona, Spain.
FAU - Zudaire, Isabel
AU  - Zudaire I
FAU - Lozano, Maria D
AU  - Lozano MD
FAU - Agorreta, Jackeline
AU  - Agorreta J
FAU - Bastarrika, Gorka
AU  - Bastarrika G
FAU - Torre, Wenceslao
AU  - Torre W
FAU - Remirez, Ana
AU  - Remirez A
FAU - Pio, Ruben
AU  - Pio R
FAU - Zulueta, Javier J
AU  - Zulueta JJ
FAU - Montuenga, Luis M
AU  - Montuenga LM
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adenocarcinoma/diagnostic imaging/*genetics/pathology
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Squamous Cell/diagnostic imaging/*genetics/pathology
MH  - Early Diagnosis
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/diagnostic imaging/*genetics/pathology
MH  - Mass Screening
MH  - Neoplasm Staging
MH  - Phenotype
MH  - Sensitivity and Specificity
MH  - Smoking
MH  - *Tomography, Spiral Computed
EDAT- 2006/02/24 09:00
MHDA- 2006/06/16 09:00
CRDT- 2006/02/24 09:00
PHST- 2006/02/24 09:00 [pubmed]
PHST- 2006/06/16 09:00 [medline]
PHST- 2006/02/24 09:00 [entrez]
AID - 15/2/373 [pii]
AID - 10.1158/1055-9965.EPI-05-0320 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):373-80. doi: 
      10.1158/1055-9965.EPI-05-0320.