PMID- 16492971
OWN - NLM
STAT- MEDLINE
DCOM- 20060502
LR  - 20131121
IS  - 0031-3998 (Print)
IS  - 0031-3998 (Linking)
VI  - 59
IP  - 3
DP  - 2006 Mar
TI  - Dietary zinc supplementation ameliorates LPS-induced teratogenicity in mice.
PG  - 355-8
AB  - Maternal infection during the first trimester of pregnancy has been associated 
      with preterm birth, spontaneous abortion, growth retardation, and congenital 
      anomalies. Previously, our group has shown that subcutaneous injection of zinc 
      prevents endotoxin [lipopolysaccharide (LPS)]-induced teratogenicity. The purpose 
      of this study was to investigate whether increasing or decreasing dietary zinc 
      alters the teratogenic effects of LPS. Female C57BL6 mice were mated and fed 
      diets containing 5, 35, or 100 mg/kg zinc. On gestational day (GD) 8, pregnant 
      dams were injected with either LPS (0.5 mg/kg s.c.) or saline and killed on GD18. 
      LPS-treated fetuses from dams fed 5 and 35 mg/kg zinc diet had a significantly 
      higher number of abnormalities per litter (2- and 1- fold saline controls, 
      respectively) compared with those from LPS + zinc supplemented dams, which were 
      not significantly different from the saline control groups. The beneficial effect 
      and importance of zinc was also reflected in the larger size of fetuses (weight 
      and crown-rump length) from the LPS + zinc-supplemented treatment group. We have 
      demonstrated that low dietary zinc during exposure to infection (i.e. LPS) in 
      pregnancy augments the negative impact of LPS alone, and that dietary zinc 
      supplementation throughout pregnancy ameliorates LPS-induced teratogenicity.
FAU - Chua, Joanne S C
AU  - Chua JS
AD  - Division of Clinical Biochemistry, Hanson Institute, Australia.
FAU - Rofe, Allan M
AU  - Rofe AM
FAU - Coyle, Peter
AU  - Coyle P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Teratogens)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Diet
MH  - *Dietary Supplements
MH  - Female
MH  - Fetus/abnormalities/anatomy & histology/drug effects
MH  - Humans
MH  - Lipopolysaccharides/pharmacology/*toxicity
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pregnancy
MH  - Teratogens/pharmacology/*toxicity
MH  - Zinc/*administration & dosage
EDAT- 2006/02/24 09:00
MHDA- 2006/05/04 09:00
CRDT- 2006/02/24 09:00
PHST- 2006/02/24 09:00 [pubmed]
PHST- 2006/05/04 09:00 [medline]
PHST- 2006/02/24 09:00 [entrez]
AID - 59/3/355 [pii]
AID - 10.1203/01.pdr.0000199906.37619.9c [doi]
PST - ppublish
SO  - Pediatr Res. 2006 Mar;59(3):355-8. doi: 10.1203/01.pdr.0000199906.37619.9c.