PMID- 16493618
OWN - NLM
STAT- MEDLINE
DCOM- 20060413
LR  - 20081121
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 81
IP  - 3
DP  - 2006 Mar
TI  - Acute myeloid leukemia of donor origin after allogeneic bone marrow 
      transplantation for precursor T-cell acute lymphoblastic leukemia: case report 
      and review of the literature.
PG  - 178-85
AB  - We report a case of donor-derived acute myeloid leukemia (AML) occurring in a 
      33-year-old man after allogeneic bone marrow transplantation (BMT) for precursor 
      T-cell acute lymphoblastic -leukemia (T-ALL). The cells for BMT were from his 
      human leukocyte antigen (HLA)-matched sister. Fluorescence in-situ hybridization 
      (FISH) analysis showed the AML to be of donor origin (i.e., karyotypically 
      female) with an 11q23 (mixed lineage leukemia (MLL) gene) translocation, while 
      the original T-ALL exhibited a male karyotype with abnormalities of chromosomes 
      6, 8, and a t(10;14)(q24;q11.2). Subsequent molecular short tandem repeat studies 
      confirmed the AML to be of donor origin. Donor-cell leukemia (DCL) after 
      allogeneic BMT is a rare, yet well-documented, event. Our report presents 
      clinicopathologic information about a case of DCL and a review of the recent 
      literature.
FAU - Reichard, Kaaren K
AU  - Reichard KK
AD  - Department of Pathology, University of New Mexico, Albuquerque, 87131, USA. 
      kreichard@salud.unm.edu
FAU - Zhang, Qian-Yun
AU  - Zhang QY
FAU - Sanchez, Lorraine
AU  - Sanchez L
FAU - Hozier, John
AU  - Hozier J
FAU - Viswanatha, David
AU  - Viswanatha D
FAU - Foucar, Kathryn
AU  - Foucar K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
SB  - IM
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - Chromosome Aberrations
MH  - Chromosomes, Human/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*etiology/genetics/pathology
MH  - *Living Donors
MH  - Male
MH  - Neoplasms, Second Primary/*etiology/genetics/pathology
MH  - Precursor T-Cell Lymphoblastic 
      Leukemia-Lymphoma/complications/genetics/pathology/*therapy
MH  - *Transplantation Chimera
MH  - Transplantation, Homologous
EDAT- 2006/02/24 09:00
MHDA- 2006/04/14 09:00
CRDT- 2006/02/24 09:00
PHST- 2006/02/24 09:00 [pubmed]
PHST- 2006/04/14 09:00 [medline]
PHST- 2006/02/24 09:00 [entrez]
AID - 10.1002/ajh.20389 [doi]
PST - ppublish
SO  - Am J Hematol. 2006 Mar;81(3):178-85. doi: 10.1002/ajh.20389.