PMID- 16494036
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20211203
VI  - 19
IP  - 21
DP  - 2005 Nov
TI  - [Expression and clinical significance of p185 and CD44v6 in laryngeal squamous 
      cell carcinoma].
PG  - 964-6
AB  - OBJECTIVE: To investigate the expression and the clinical significance of 
      proto-oncogene cerbB-2 proteins p185 and adhesion molecules CD44v6 in laryngeal 
      squamous cell carcinomas (LSCC) and the relationship between them. METHOD: 
      expression of p185 and CD44v6 was studied by immunohistochemical analysis from 63 
      cases of LSCC, 20 cases of adjacent safety margin (ASM) and 18 cases of vocal 
      cord polyp(VCP). RESULT: There were no expression of p185in VCP, Significant 
      differences (P < 0.05) were observed between the two group; there was significant 
      differences among the different pathologic degree I, II, III; The expression of 
      p185 was not related to age and clinical stage. Significant differences (P < 
      0.05) were found among LSCC, VCP and ASM; there was no differences between the 
      different pathologic degree I, II, III. The expression of CD44v6 was not related 
      to age and clinical stage. Significant correlation was observed between the 
      expression of p185 and CD44v6 in LSCC. CONCLUSION: p185 probably plays an 
      important role during the carcinogenesis and progression process of LSCC. While 
      CD44v6 has the important function only in the carcinogenesis process of LSCC. The 
      expression of p185 and CD44v6 were higher in ASM than in VCP. It indicates that 
      p185 and CD44v6 were probably the unstable factor in ASM which related to the 
      recurrent of laryngeal carcinoma, and they may cooperate with each other.
FAU - Wang, Xiaoqian
AU  - Wang X
AD  - Department of Otorhinolaryngology, the First Affiliated Hospital of Jinan 
      University, Guangzhou, 510630, China.
FAU - Wang, Jiqun
AU  - Wang J
FAU - Shan, Yanchun
AU  - Shan Y
FAU - Jia, Haiying
AU  - Jia H
FAU - He, Long
AU  - He L
FAU - Luo, Sijin
AU  - Luo S
FAU - Zhang, Tao
AU  - Zhang T
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (CD44v6 antigen)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Hyaluronan Receptors/*metabolism
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Proto-Oncogene Mas
MH  - Receptor, ErbB-2/*metabolism
EDAT- 2006/02/24 09:00
MHDA- 2011/04/06 06:00
CRDT- 2006/02/24 09:00
PHST- 2006/02/24 09:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
PHST- 2006/02/24 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Nov;19(21):964-6.