PMID- 16494850
OWN - NLM
STAT- MEDLINE
DCOM- 20060522
LR  - 20181201
IS  - 0006-2952 (Print)
IS  - 0006-2952 (Linking)
VI  - 71
IP  - 9
DP  - 2006 Apr 28
TI  - Hydroxyl radical scavenging reactivity of proton pump inhibitors.
PG  - 1337-41
AB  - In addition to the established control of acid secretion of the class of proton 
      pump inhibitors (PPI) reactivity from the pyridyl methyl sulphinyl benzimidazole 
      type a second independent anti-inflammatory reactivity was observed in vitro. 
      This inhibitory reactivity was clearly noticed using three different assays where 
      the aggressive hydroxyl radicals were successfully trapped in a concentration 
      dependent manner. There is unequivocal evidence that the proton pump inhibitors 
      having the sulphoxide group are able to scavenge hydroxyl radicals which are 
      generated during a Fenton reaction. By way of contrast, the corresponding 
      thioethers were substantially less active. No detectable effect was seen in the 
      superoxide radical scavenging system. In conclusion, pantoprazole as well as the 
      other proton pump inhibitors have a pronounced inhibitory reactivity towards 
      hydroxyl radicals.
FAU - Simon, Wolfgang Alexander
AU  - Simon WA
AD  - ALTANA Pharma AG, Byk Guldenstrasse 2, D 78464 Konstanz, Germany. 
      simon@altanapharma.com
FAU - Sturm, Ernst
AU  - Sturm E
FAU - Hartmann, Hans-Jurgen
AU  - Hartmann HJ
FAU - Weser, Ulrich
AU  - Weser U
LA  - eng
PT  - Journal Article
DEP - 20060221
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Benzimidazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Iron Compounds)
RN  - 0 (Proton Pumps)
RN  - 0 (Sulfides)
RN  - 0 (Sulfoxides)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - 3352-57-6 (Hydroxyl Radical)
RN  - 42VZT0U6YR (Heme)
RN  - 533-67-5 (Deoxyribose)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - D8TST4O562 (Pantoprazole)
RN  - KG60484QX9 (Omeprazole)
RN  - LRX7AJ16DT (Copper Sulfate)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Animals
MH  - Benzimidazoles/*chemistry
MH  - Cattle
MH  - Copper Sulfate/chemistry
MH  - Deoxyribose/chemistry
MH  - Enzyme Inhibitors/chemistry
MH  - Erythrocytes
MH  - Free Radical Scavengers/*chemistry
MH  - Heme/chemistry
MH  - Hyaluronic Acid/chemistry
MH  - Hydroxyl Radical/*chemistry
MH  - Iron Compounds/chemistry
MH  - Lansoprazole
MH  - Omeprazole/*analogs & derivatives/chemistry
MH  - Pantoprazole
MH  - Proton Pumps/*chemistry
MH  - Sulfides/chemistry
MH  - Sulfoxides/*chemistry
EDAT- 2006/02/24 09:00
MHDA- 2006/05/23 09:00
CRDT- 2006/02/24 09:00
PHST- 2005/11/29 00:00 [received]
PHST- 2006/01/16 00:00 [revised]
PHST- 2006/01/17 00:00 [accepted]
PHST- 2006/02/24 09:00 [pubmed]
PHST- 2006/05/23 09:00 [medline]
PHST- 2006/02/24 09:00 [entrez]
AID - S0006-2952(06)00060-8 [pii]
AID - 10.1016/j.bcp.2006.01.009 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2006 Apr 28;71(9):1337-41. doi: 10.1016/j.bcp.2006.01.009. 
      Epub 2006 Feb 21.