PMID- 16495573
OWN - NLM
STAT- MEDLINE
DCOM- 20060605
LR  - 20181113
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 74
IP  - 3
DP  - 2006 Mar
TI  - Modulation of human neutrophil functions in vitro by Treponema denticola major 
      outer sheath protein.
PG  - 1954-7
AB  - In this study of human polymorphonuclear leukocytes (PMNs), pretreatment with 
      Treponema denticola major outer sheath protein (Msp) inhibited 
      formyl-methionyl-leucyl-phenylalanine (fMLP)-induced chemotaxis, phagocytosis of 
      immunoglobulin G-coated microspheres, fMLP-stimulated calcium transients, and 
      actin assembly. Msp neither altered oxidative responses to phorbol myristate or 
      fMLP nor induced apoptosis. Msp selectively impairs chemotaxis and phagocytosis 
      by impacting the PMN cytoskeleton.
FAU - Puthengady Thomas, Bina
AU  - Puthengady Thomas B
AD  - CIHR Group in Matrix Dynamics and Dental Research Institute, Faculty of 
      Dentistry, University of Toronto, Toronto, Ontario, Canada M5S 3E2.
FAU - Sun, Chun Xiang
AU  - Sun CX
FAU - Bajenova, Elena
AU  - Bajenova E
FAU - Ellen, Richard P
AU  - Ellen RP
FAU - Glogauer, Michael
AU  - Glogauer M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Bacterial Proteins)
RN  - 0 (Porins)
RN  - 0 (major outer sheath protein, Treponema)
SB  - IM
MH  - Bacterial Proteins/metabolism/*pharmacology
MH  - Chemotaxis, Leukocyte/*drug effects
MH  - Humans
MH  - Neutrophils/*drug effects/physiology
MH  - Phagocytosis/drug effects
MH  - Porins/metabolism/*pharmacology
MH  - Treponema denticola/*chemistry
PMC - PMC1418645
EDAT- 2006/02/24 09:00
MHDA- 2006/06/06 09:00
PMCR- 2006/07/01
CRDT- 2006/02/24 09:00
PHST- 2006/02/24 09:00 [pubmed]
PHST- 2006/06/06 09:00 [medline]
PHST- 2006/02/24 09:00 [entrez]
PHST- 2006/07/01 00:00 [pmc-release]
AID - 74/3/1954 [pii]
AID - 1437-05 [pii]
AID - 10.1128/IAI.74.3.1954-1957.2006 [doi]
PST - ppublish
SO  - Infect Immun. 2006 Mar;74(3):1954-7. doi: 10.1128/IAI.74.3.1954-1957.2006.