PMID- 16496494
OWN - NLM
STAT- MEDLINE
DCOM- 20060314
LR  - 20191109
IS  - 1556-3650 (Print)
IS  - 1556-3650 (Linking)
VI  - 44
IP  - 1
DP  - 2006
TI  - The Leiden mutation and activated protein C resistance as risk factors for 
      disseminated intravascular coagulation in acutely poisoned patients.
PG  - 53-7
AB  - The aim of this work was to assess the prevalence of a genetic predisposition to 
      disseminated intravascular coagulation (DIC) among acutely poisoned patients. 
      Activated protein C resistence (APCR) is a genetically determined cause of 
      thrombophilia and DIC development. One hundred seventy-six subjects were divided 
      into three groups: one consisted of 83 acutely poisoned patients with DIC; a 
      second consisted of 57 acutely poisoned patients without DIC; the third group 
      consisted of 91 healthy controls. Abnormal results of APCR testing were found in 
      24.1% of the poisoned DIC group, 5.3% of the poisoned nonDIC group, and 3.3% of 
      the control group. Genetic tests were performed in 37 selected patients. Factor V 
      Leiden mutation (G/A genotype) was determined to be present in people whose R 
      index value was below 1.9. These results raise the possibility that outcomes of 
      acute poisonings may be influenced by genetic predisposition.
FAU - Prazanowski, Miroslaw
AU  - Prazanowski M
AD  - Immunotoxicology Department Nofer Institute of Occupational Medicine in Lodz, 
      Lodz, Poland.
FAU - Kur, Barbara
AU  - Kur B
FAU - Baranska, Malgorzata
AU  - Baranska M
FAU - Lutz, Waldemar
AU  - Lutz W
FAU - Pilacik, Bozena
AU  - Pilacik B
FAU - Kolacinski, Zbigniew
AU  - Kolacinski Z
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Toxicol (Phila)
JT  - Clinical toxicology (Philadelphia, Pa.)
JID - 101241654
RN  - 0 (Xenobiotics)
RN  - 0 (factor V Leiden)
RN  - 9001-24-5 (Factor V)
SB  - IM
MH  - Activated Protein C Resistance/blood/*genetics
MH  - Acute Disease
MH  - Adult
MH  - Blood Coagulation Tests
MH  - Disseminated Intravascular Coagulation/blood/*genetics
MH  - Factor V/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Middle Aged
MH  - *Point Mutation
MH  - Poisoning/blood/genetics
MH  - Prevalence
MH  - Risk Factors
MH  - Xenobiotics/*poisoning
EDAT- 2006/02/25 09:00
MHDA- 2006/03/15 09:00
CRDT- 2006/02/25 09:00
PHST- 2006/02/25 09:00 [pubmed]
PHST- 2006/03/15 09:00 [medline]
PHST- 2006/02/25 09:00 [entrez]
AID - 10.1080/15563650500394845 [doi]
PST - ppublish
SO  - Clin Toxicol (Phila). 2006;44(1):53-7. doi: 10.1080/15563650500394845.