PMID- 1649689
OWN - NLM
STAT- MEDLINE
DCOM- 19910828
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 68
IP  - 4
DP  - 1991 Aug 15
TI  - First heterotransplantation of a human carcinoid tumor into nude mice.
PG  - 893-902
AB  - The first successful heterotransplantation of a human carcinoid tumor into nude 
      mice is reported. CSH, a voluminous hepatic metastasis of a primary bronchial 
      carcinoid tumor (CSB) was resected and transplanted into three irradiated nude 
      (Swiss-nu/nu) mice both by subcutaneous (SC) and intramuscular (IM) routes; the 
      success rate was five of six. Heterotransplanted tumors took 4 to 5 months to 
      appear in the mice and 1 month to attain a width of 0.5 cm. Both human and mouse 
      tumors (named CSH-SC and CSH-IM) were studied by light and electron microscopy. 
      They were Grimelius-positive, neuron-specific enolase-positive, and 
      bombesin-negative by immunocytochemistry. Furthermore, CSH-SC cells presented 
      characteristic (pear-shaped, rod-shaped, or tadpole-shaped) neurosecretory 
      granules. Although CSB and CSH were slightly serotonin positive by 
      immunocytochemistry, only a few serotonin-positive cells were found in CSH-SC and 
      none in CSH-IM, suggesting partial loss of differentiation or an increase in 
      serotonin catabolism during transplantation.
FAU - Ganem, Y J
AU  - Ganem YJ
AD  - Service de Biochimie et Neurobiologie, Hopital Saint-Louis, Paris, France.
FAU - Launay, J M
AU  - Launay JM
FAU - Debons-Guillemin, M C
AU  - Debons-Guillemin MC
FAU - Lasneret, J
AU  - Lasneret J
FAU - Roucayrol, A M
AU  - Roucayrol AM
FAU - Lesser, J
AU  - Lesser J
FAU - Peries, G
AU  - Peries G
FAU - Dreux, C
AU  - Dreux C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Bronchial Neoplasms/chemistry/*pathology
MH  - Carcinoma, Adenoid Cystic/chemistry/*pathology/secondary
MH  - Humans
MH  - Immunohistochemistry
MH  - Injections, Intramuscular
MH  - Injections, Subcutaneous
MH  - Liver Neoplasms/chemistry/*pathology/secondary
MH  - Male
MH  - Mice
MH  - Mice, Nude
MH  - Microscopy
MH  - Microscopy, Electron
MH  - Neoplasm Transplantation/*methods
MH  - Serotonin/analysis/blood
MH  - Transplantation, Heterologous
MH  - Whole-Body Irradiation
EDAT- 1991/08/15 00:00
MHDA- 1991/08/15 00:01
CRDT- 1991/08/15 00:00
PHST- 1991/08/15 00:00 [pubmed]
PHST- 1991/08/15 00:01 [medline]
PHST- 1991/08/15 00:00 [entrez]
AID - 10.1002/1097-0142(19910815)68:4<893::aid-cncr2820680436>3.0.co;2-e [doi]
PST - ppublish
SO  - Cancer. 1991 Aug 15;68(4):893-902. doi: 
      10.1002/1097-0142(19910815)68:4<893::aid-cncr2820680436>3.0.co;2-e.