PMID- 16497295
OWN - NLM
STAT- MEDLINE
DCOM- 20060607
LR  - 20121115
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 534
IP  - 1-3
DP  - 2006 Mar 18
TI  - Caffeic acid attenuates the decrease in cortical BDNF mRNA expression induced by 
      exposure to forced swimming stress in mice.
PG  - 115-21
AB  - We previously reported that caffeic acid produces antidepressive-like effects in 
      the forced swimming test in mice, an animal model of depression. Increased 
      evidence suggests that brain-derived neurotrophic factor (BDNF), a member of the 
      neurotrophin family that has high affinity for the tyrosine kinase receptor B 
      (TrkB), plays an important role in the pathophysiology and treatment of 
      depression. The present study examined whether caffeic acid affects the 
      expression levels of BDNF and TrkB mRNA in brain regions of mice subjected to a 
      forced swimming test. Caffeic acid (4 mg/kg, i.p.) reduced the duration of 
      immobility of mice in the forced swimming test. The levels of BDNF mRNA in the 
      frontal cortex as well as TrkB mRNA in the amygdala were significantly decreased 
      after the forced swimming test, and the former reduction was significantly 
      inhibited by caffeic acid (4 mg/kg, i.p.). Caffeic acid (4 mg/kg, i.p.) did not 
      modify the levels of BDNF and TrkB mRNA in brain regions of naive mice. These 
      results suggest that caffeic acid can attenuate the down-regulation of BDNF 
      transcription that results from stressful conditions.
FAU - Takeda, Hiroshi
AU  - Takeda H
AD  - Department of Pharmacology, Tokyo Medical University, 6-1-1 Shinjuku, 
      Shinjuku-ku, Tokyo 160-8402, Japan. ht0417@tokyo-med.ac.jp
FAU - Tsuji, Minoru
AU  - Tsuji M
FAU - Yamada, Tomoko
AU  - Yamada T
FAU - Masuya, Jiro
AU  - Masuya J
FAU - Matsushita, Kaneaki
AU  - Matsushita K
FAU - Tahara, Masashi
AU  - Tahara M
FAU - Iimori, Makio
AU  - Iimori M
FAU - Matsumiya, Teruhiko
AU  - Matsumiya T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060221
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Caffeic Acids)
RN  - 0 (RNA, Messenger)
RN  - U2S3A33KVM (caffeic acid)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology/therapeutic use
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Caffeic Acids/*pharmacology/therapeutic use
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Depression/drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Gene Expression Regulation
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Models, Animal
MH  - RNA, Messenger/metabolism
MH  - Stress, Psychological
MH  - Swimming
MH  - Time Factors
EDAT- 2006/02/25 09:00
MHDA- 2006/06/08 09:00
CRDT- 2006/02/25 09:00
PHST- 2005/11/09 00:00 [received]
PHST- 2005/12/19 00:00 [revised]
PHST- 2006/01/18 00:00 [accepted]
PHST- 2006/02/25 09:00 [pubmed]
PHST- 2006/06/08 09:00 [medline]
PHST- 2006/02/25 09:00 [entrez]
AID - S0014-2999(06)00038-0 [pii]
AID - 10.1016/j.ejphar.2006.01.026 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2006 Mar 18;534(1-3):115-21. doi: 10.1016/j.ejphar.2006.01.026. 
      Epub 2006 Feb 21.