PMID- 16497333
OWN - NLM
STAT- MEDLINE
DCOM- 20070410
LR  - 20220129
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 41
IP  - 5
DP  - 2007 Aug
TI  - No association between the BDNF Val66Met polymorphism and mood status in a 
      non-clinical community sample of 7389 older adults.
PG  - 404-9
AB  - Recent research has suggested that brain-derived neurotrophic factor (BDNF) may 
      be implicated in the aetiology of mood-related phenotypes. Here we report an 
      investigation of the association between a BDNF coding variant (Val66Met, rs6265) 
      and mood status in a large non-clinical sample of men and women. We genotyped 
      7389 adult men and women, aged 41-80 years, selected from participants in the 
      European Prospective Investigation into Cancer and Nutrition in Norfolk 
      (EPIC-Norfolk, United Kingdom). Evidence of past year prevalent, lifetime and 
      recurrent episodic major depressive disorder (MDD) and of past year prevalent and 
      lifetime generalised anxiety disorder (GAD), defined by DSM-IV diagnostic 
      criteria, was assessed through questionnaire together with a five-item version of 
      the Mental Health Inventory (MHI-5). A total of 1214 (16.4%) participants 
      reported lifetime MDD and 355 (4.8%) reported lifetime GAD. In this population 
      based study we found no evidence to support an association between the BDNF gene 
      Val66Met polymorphism and mood status.
FAU - Surtees, Paul G
AU  - Surtees PG
AD  - Strangeways Research Laboratory and University of Cambridge, Department of Public 
      Health and Primary Care, Worts Causeway, Cambridge CB1 8RN, UK. 
      paul.surtees@srl.cam.ac.uk
FAU - Wainwright, Nicholas W J
AU  - Wainwright NW
FAU - Willis-Owen, Saffron A G
AU  - Willis-Owen SA
FAU - Sandhu, Manjinder S
AU  - Sandhu MS
FAU - Luben, Robert
AU  - Luben R
FAU - Day, Nicholas E
AU  - Day NE
FAU - Flint, Jonathan
AU  - Flint J
LA  - eng
GR  - G0300128/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060223
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA Primers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - DNA Primers/genetics
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mood Disorders/diagnosis/*genetics
MH  - Phenotype
MH  - Polymorphism, Genetic/*genetics
MH  - Prospective Studies
EDAT- 2006/02/25 09:00
MHDA- 2007/04/11 09:00
CRDT- 2006/02/25 09:00
PHST- 2005/10/14 00:00 [received]
PHST- 2005/12/07 00:00 [revised]
PHST- 2006/01/12 00:00 [accepted]
PHST- 2006/02/25 09:00 [pubmed]
PHST- 2007/04/11 09:00 [medline]
PHST- 2006/02/25 09:00 [entrez]
AID - S0022-3956(06)00018-5 [pii]
AID - 10.1016/j.jpsychires.2006.01.004 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2007 Aug;41(5):404-9. doi: 10.1016/j.jpsychires.2006.01.004. 
      Epub 2006 Feb 23.