PMID- 16497824
OWN - NLM
STAT- MEDLINE
DCOM- 20061107
LR  - 20200203
IS  - 0923-7534 (Print)
IS  - 0923-7534 (Linking)
VI  - 17
IP  - 5
DP  - 2006 May
TI  - 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) visualizes 
      follicular lymphoma irrespective of grading.
PG  - 780-4
AB  - BACKGROUND: 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) 
      has become a routine measure for staging and follow-up of patients with 
      aggressive lymphoma. By contrast, its usefulness to visualize indolent lymphomas 
      characterized by a lower cellular turnover has not clearly been defined. We have 
      investigated accuracy and clinical usefulness of 18F-FDG-PET in patients with 
      follicular lymphoma (FL). PATIENTS AND METHODS: A total of 64 patients with FL 
      WHO grade I - III (48, 5, and 11 patients) were imaged at our institution to 
      assess the value of 18F-FDG-PET for imaging of FL of different gradings. A total 
      of 115 scans (48 before therapy and 67 for response assessment after treatment) 
      were performed, and findings were compared to conventional staging including 
      CT-scan of thorax and abdomen, sonography of lymph nodes and bone marrow biopsy. 
      RESULTS: Overall, 18F-FDG-PET had a sensitivity of 98%, a specificity of 94%, a 
      positive predictive value of 95% and a negative predictive value of 98%. These 
      results were significantly more accurate (P = 0.023) than the conventional 
      radiology studies. There was no significant difference (P = 0.093) in the 
      accuracy between patients with indolent (WHO grade I and II) versus aggressive FL 
      (WHO grade III). CONCLUSION: 18F-FDG-PET scan is a reliable method for staging 
      and follow up of patients with nodal FL irrespective of tumor grading.
FAU - Wohrer, S
AU  - Wohrer S
AD  - Department of Internal Medicine I, Nuclear Medicine and Radiology, Medical 
      University Vienna, Austria.
FAU - Jaeger, U
AU  - Jaeger U
FAU - Kletter, K
AU  - Kletter K
FAU - Becherer, A
AU  - Becherer A
FAU - Hauswirth, A
AU  - Hauswirth A
FAU - Turetschek, K
AU  - Turetschek K
FAU - Raderer, M
AU  - Raderer M
FAU - Hoffmann, M
AU  - Hoffmann M
LA  - eng
PT  - Journal Article
DEP - 20060223
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical 
      Oncology
JID - 9007735
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Female
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Lymphoma, B-Cell/*diagnostic imaging
MH  - Lymphoma, Follicular/*diagnostic imaging
MH  - Lymphoma, Large B-Cell, Diffuse/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - *Positron-Emission Tomography
MH  - *Radiopharmaceuticals
MH  - Retrospective Studies
EDAT- 2006/02/25 09:00
MHDA- 2006/11/09 09:00
CRDT- 2006/02/25 09:00
PHST- 2006/02/25 09:00 [pubmed]
PHST- 2006/11/09 09:00 [medline]
PHST- 2006/02/25 09:00 [entrez]
AID - S0923-7534(19)47581-9 [pii]
AID - 10.1093/annonc/mdl014 [doi]
PST - ppublish
SO  - Ann Oncol. 2006 May;17(5):780-4. doi: 10.1093/annonc/mdl014. Epub 2006 Feb 23.