PMID- 16497990
OWN - NLM
STAT- MEDLINE
DCOM- 20060512
LR  - 20220317
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Linking)
VI  - 26
IP  - 5
DP  - 2006 May
TI  - Advanced oxidation protein products accelerate atherosclerosis through promoting 
      oxidative stress and inflammation.
PG  - 1156-62
AB  - OBJECTIVE: Increased level of plasma advanced oxidation protein products (AOPPs) 
      has been found in patients with uremia and nonuremic subjects with coronary 
      artery disease. This study was conducted to test the hypothesis that AOPPs play a 
      causal role in atherosclerosis. METHODS AND RESULTS: Hypercholesterolemic (0.5% 
      wt/wt diet) or normal rabbits received either repeated intravenous injections of 
      AOPPs modified rabbit serum albumin (AOPPs-RSA) or unmodified RSA for 8 weeks. 
      Compared with RSA- or vehicle-treated hypercholesterolemic rabbits, 
      AOPPs-RSA-treated animals displayed increased atherosclerotic plaque area 
      oxidized low-density lipoprotein (oxLDL) deposition, macrophage infiltration, and 
      smooth muscle cell proliferation. Aortic sections from AOPPs-RSA-treated normal 
      rabbits showed significant focal intima proliferation and mild Oil-Red-O staining 
      lipid deposition in the affected areas, a phenomenon not observed in the RSA- or 
      vehicle-treated controls. Plasma AOPPs levels in AOPPs-treated groups 
      significantly increased in both hypercholesterolemic and normal rabbits compared 
      with their relevant controls. Close correlations were found between plasma levels 
      of AOPPs and the parameters of oxidative stress, eg, oxLDL and thiobarbituric 
      acid reactive substances levels, or glutathione peroxidase activity. A highly 
      significant correlation was also observed between plasma AOPPs and tumor necrosis 
      factor (TNF)-alpha levels. CONCLUSIONS: This study provides in vivo evidence for 
      a causal relationship between chronic AOPPs accumulation and atherosclerosis.
FAU - Liu, Shang Xi
AU  - Liu SX
AD  - Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 
      510515, PR China.
FAU - Hou, Fan Fan
AU  - Hou FF
FAU - Guo, Zhi Jian
AU  - Guo ZJ
FAU - Nagai, Ryoji
AU  - Nagai R
FAU - Zhang, Wei Ru
AU  - Zhang WR
FAU - Liu, Zhi Qiang
AU  - Liu ZQ
FAU - Zhou, Zhan Mei
AU  - Zhou ZM
FAU - Zhou, Mei
AU  - Zhou M
FAU - Xie, Di
AU  - Xie D
FAU - Wang, Guo Bao
AU  - Wang GB
FAU - Zhang, Xun
AU  - Zhang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060223
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
RN  - 0 (Blood Proteins)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (oxidized low density lipoprotein)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/*etiology
MH  - Blood Proteins/*metabolism
MH  - Cell Proliferation
MH  - Female
MH  - Glycation End Products, Advanced/blood
MH  - Inflammation/*complications
MH  - Lipoproteins, LDL/metabolism
MH  - Macrophages/physiology
MH  - Muscle, Smooth, Vascular/pathology
MH  - Myocytes, Smooth Muscle/pathology
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Rabbits
MH  - Thiobarbituric Acid Reactive Substances/analysis
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 2006/02/25 09:00
MHDA- 2006/05/13 09:00
CRDT- 2006/02/25 09:00
PHST- 2006/02/25 09:00 [pubmed]
PHST- 2006/05/13 09:00 [medline]
PHST- 2006/02/25 09:00 [entrez]
AID - 01.ATV.0000214960.85469.68 [pii]
AID - 10.1161/01.ATV.0000214960.85469.68 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2006 May;26(5):1156-62. doi: 
      10.1161/01.ATV.0000214960.85469.68. Epub 2006 Feb 23.