PMID- 16498064
OWN - NLM
STAT- MEDLINE
DCOM- 20060420
LR  - 20201209
IS  - 0804-4643 (Print)
IS  - 0804-4643 (Linking)
VI  - 154
IP  - 3
DP  - 2006 Mar
TI  - Novel neuroanatomical pathways for thyroid hormone action in the human anterior 
      pituitary.
PG  - 491-500
AB  - OBJECTIVE: An increasing number of proteins appear to be involved in thyroid 
      hormone feedback action at the level of the anterior pituitary, but the cell 
      types expressing these proteins are largely unknown. The aim of the present study 
      was to identify cell types in the human anterior pituitary that express type II 
      and type III deiodinase (D2 and D3), the recently described thyroid hormone 
      transporter (MCT8) and thyroid hormone receptor (TR) isoforms by means of 
      double-labeling immunocytochemistry. RESULTS: We found TR isoforms to be 
      expressed most prominently in gonadotropes and - although to a lesser extent - in 
      thyrotropes, corticotropes, lactotropes and somatotropes. D3 staining showed a 
      distribution pattern that was remarkably similar. By contrast, D2 
      immunoreactivity was observed exclusively in folliculostellate (FS) cells showing 
      coexpression with human leukocyte antigen (HLA), a marker of major 
      histocompatibility complex (MHC)-class II. MCT8 immunostaining was present in FS 
      cells without HLA coexpression. CONCLUSIONS: From these results, we propose a 
      novel neuroanatomical model for thyroid hormone feedback on the human pituitary, 
      with a central role for FS cells in thyroid hormone activation, which thus play 
      an important role in the suppression of TSH secretion by circulating thyroxine 
      (T(4)).
FAU - Alkemade, Anneke
AU  - Alkemade A
AD  - Department of Endocrinology and Metabolism, Academic Medical Center, University 
      of Amsterdam, The Netherlands.
FAU - Friesema, Edith C
AU  - Friesema EC
FAU - Kuiper, George G
AU  - Kuiper GG
FAU - Wiersinga, Wilmar M
AU  - Wiersinga WM
FAU - Swaab, Dick F
AU  - Swaab DF
FAU - Visser, Theo J
AU  - Visser TJ
FAU - Fliers, Eric
AU  - Fliers E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Isoenzymes)
RN  - 0 (Monocarboxylic Acid Transporters)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (SLC16A2 protein, human)
RN  - 0 (Symporters)
RN  - 0 (Thyroid Hormones)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Aged
MH  - Antibodies, Monoclonal
MH  - Feedback
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Immunohistochemistry
MH  - Iodide Peroxidase/metabolism
MH  - Isoenzymes/metabolism
MH  - Male
MH  - Middle Aged
MH  - Monocarboxylic Acid Transporters/metabolism
MH  - Pituitary Gland, Anterior/*physiology
MH  - Receptors, Thyroid Hormone/metabolism
MH  - Signal Transduction/physiology
MH  - Symporters
MH  - Thyroid Hormones/*physiology
MH  - Thyroxine/metabolism
EDAT- 2006/02/25 09:00
MHDA- 2006/04/21 09:00
CRDT- 2006/02/25 09:00
PHST- 2006/02/25 09:00 [pubmed]
PHST- 2006/04/21 09:00 [medline]
PHST- 2006/02/25 09:00 [entrez]
AID - 154/3/491 [pii]
AID - 10.1530/eje.1.02111 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2006 Mar;154(3):491-500. doi: 10.1530/eje.1.02111.