PMID- 16498791
OWN - NLM
STAT- MEDLINE
DCOM- 20060316
LR  - 20161018
IS  - 1019-5297 (Print)
IS  - 1019-5297 (Linking)
IP  - 8
DP  - 2005 Dec
TI  - [Effect of alpha-difluoromethylornithine and polyhexamethyleneguanidine (PMG), 
      polyamine biosynthesis inhibitors on leucosis L1210 growth kinetics and life 
      expectancy of animals with cancer].
PG  - 76-81
AB  - The article deals with the study of polyamines content and 
      y-glutamiltranspeptidase (gamma-GTP) activity in leucosis L1210 cells under the 
      influence of inhibitors of polyamines synthesis such as 
      alpha-difluoromethylornithine (alpha-DFMO) and polyhexamethylenguanidine (PMG). 
      Injections of alpha-DFMO and PMG to animals essentially reduce putrescine and 
      spermidine concentrations, and the levels of spermine and gamma-GTP activity 
      increase under this influence. These modulation were associated with L1210 
      leucosis growth retardation. Antiblastic effect was dependent on inhibitors' 
      doses and mode of injections' course. Under the optimum conditions the 
      retardation index was 90-98%. The animals with retarded tumor growth had 
      essentially longer survival time frame than blank tumor-bearing animals (index 
      was 37.2 for a-DFMO and 67.5 for PMG).
FAU - Zaletok, S P
AU  - Zaletok SP
FAU - Berdinskikh, N K
AU  - Berdinskikh NK
FAU - Lialiushko, N M
AU  - Lialiushko NM
FAU - Klenov, O A
AU  - Klenov OA
FAU - Samoilenko, E A
AU  - Samoilenko EA
FAU - Lidak, M Iu
AU  - Lidak MIu
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Ukraine
TA  - Lik Sprava
JT  - Likars'ka sprava
JID - 9601540
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Biogenic Polyamines)
RN  - 0 (Guanidines)
RN  - 31961-54-3 (polyhexamethyleneguanidine)
RN  - ZQN1G5V6SR (Eflornithine)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology/*therapeutic use
MH  - Biogenic Polyamines/antagonists & inhibitors/*biosynthesis
MH  - Eflornithine/pharmacology/*therapeutic use
MH  - Guanidines/pharmacology/*therapeutic use
MH  - Kinetics
MH  - Leukemia L1210/*drug therapy/metabolism/pathology
MH  - Life Expectancy
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Neoplasm Transplantation
EDAT- 2006/02/28 09:00
MHDA- 2006/03/17 09:00
CRDT- 2006/02/28 09:00
PHST- 2006/02/28 09:00 [pubmed]
PHST- 2006/03/17 09:00 [medline]
PHST- 2006/02/28 09:00 [entrez]
PST - ppublish
SO  - Lik Sprava. 2005 Dec;(8):76-81.