PMID- 16500365
OWN - NLM
STAT- MEDLINE
DCOM- 20060321
LR  - 20131121
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 85
IP  - 3
DP  - 2006 Mar
TI  - Association of cryptorchidism with Gly146Ala polymorphism in the gene for 
      steroidogenic factor-1.
PG  - 787-90
AB  - Genotyping analysis was performed for Gly146Ala polymorphism in the gene for 
      steroidogenic factor-1 (SF-1), which is known to reduce the transactivation 
      function by approximately 20%, in 72 cryptorchid patients and 136 control males, 
      revealing that the Ala allele, the Ala/Gly genotype, and the Ala/Ala plus Ala/Gly 
      genotype frequencies were significantly higher in the patients than in the 
      control males. The results suggest that the Gly146Ala polymorphism may be a 
      susceptibility factor for the development of cryptorchidism (CO).
FAU - Wada, Yuka
AU  - Wada Y
AD  - Department of Endocrinology and Metabolism, National Research Institute for Child 
      Health and Development, Tokyo, Japan.
FAU - Okada, Michiyo
AU  - Okada M
FAU - Fukami, Maki
AU  - Fukami M
FAU - Sasagawa, Isoji
AU  - Sasagawa I
FAU - Ogata, Tsutomu
AU  - Ogata T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Homeodomain Proteins)
RN  - 0 (NR5A1 protein, human)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Steroidogenic Factor 1)
RN  - 0 (Transcription Factors)
RN  - OF5P57N2ZX (Alanine)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Adolescent
MH  - Alanine
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cryptorchidism/*genetics
MH  - Gene Frequency
MH  - Genotype
MH  - Glycine
MH  - Homeodomain Proteins/*genetics
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Receptors, Cytoplasmic and Nuclear/*genetics
MH  - Steroidogenic Factor 1
MH  - Transcription Factors/*genetics
EDAT- 2006/02/28 09:00
MHDA- 2006/03/22 09:00
CRDT- 2006/02/28 09:00
PHST- 2005/03/03 00:00 [received]
PHST- 2005/09/05 00:00 [revised]
PHST- 2005/09/05 00:00 [accepted]
PHST- 2006/02/28 09:00 [pubmed]
PHST- 2006/03/22 09:00 [medline]
PHST- 2006/02/28 09:00 [entrez]
AID - S0015-0282(05)03981-6 [pii]
AID - 10.1016/j.fertnstert.2005.09.016 [doi]
PST - ppublish
SO  - Fertil Steril. 2006 Mar;85(3):787-90. doi: 10.1016/j.fertnstert.2005.09.016.