PMID- 16501634
OWN - NLM
STAT- MEDLINE
DCOM- 20061108
LR  - 20121115
IS  - 1743-4297 (Print)
IS  - 1743-4297 (Linking)
VI  - 3 Suppl 1
DP  - 2006 Mar
TI  - Bone-marrow-derived cell transfer after ST-elevation myocardial infarction: 
      lessons from the BOOST trial.
PG  - S65-8
AB  - Emerging evidence suggests that bone-marrow-derived stem and progenitor cells can 
      be used to improve cardiac function after acute myocardial infarction. We tested 
      this concept in the randomized, controlled, BOOST (bone marrow transfer to 
      enhance ST-elevation infarct regeneration) clinical trial. Following successful 
      percutaneous coronary intervention for acute ST-elevation myocardial infarction, 
      patients received an intracoronary transfer of autologous bone marrow cells 
      (BMCs). After 6 months, global left ventricular ejection fraction, as determined 
      by magnetic resonance imaging, was significantly improved in the BMC-treated 
      group compared with the control group. BMC transfer enhanced left ventricular 
      systolic function, primarily in myocardial segments adjacent to the infarcted 
      area, and also had a positive effect on diastolic function. BMC transfer did not 
      increase the risk of adverse clinical events and did not promote in-stent 
      re-stenosis or proarrhythmic effects. In principle, the effects of BMC transfer 
      on ejection fraction were sustained at 18-month follow-up. Notably, radioactive 
      labeling of BMCs and positron emission tomography showed that these beneficial 
      effects are achieved with limited cardiac homing of BMCs after intracoronary 
      application. Taken together, our studies indicate that intracoronary transfer of 
      autologous BMCs is a safe, promising, and novel approach to further improving 
      systolic function in patients with successful reperfusion after acute myocardial 
      infarction.
FAU - Drexler, Helmut
AU  - Drexler H
AD  - Department of Cardiology and Angiology at Hannover Medical School, Hannover, 
      Germany. drexler.helmut@mh-hannover.de
FAU - Meyer, Gerd P
AU  - Meyer GP
FAU - Wollert, Kai C
AU  - Wollert KC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nat Clin Pract Cardiovasc Med
JT  - Nature clinical practice. Cardiovascular medicine
JID - 101226507
SB  - IM
MH  - Bone Marrow Cells/*cytology/physiology
MH  - *Cardiac Catheterization
MH  - Cell Movement
MH  - Follow-Up Studies
MH  - Humans
MH  - Myocardial Infarction/physiopathology/*therapy
MH  - *Myocardium/cytology/immunology
MH  - Randomized Controlled Trials as Topic
MH  - *Stem Cell Transplantation
MH  - Stroke Volume
MH  - Transplantation, Autologous
MH  - Treatment Outcome
MH  - Ventricular Function, Left
EDAT- 2006/02/28 09:00
MHDA- 2006/11/10 09:00
CRDT- 2006/02/28 09:00
PHST- 2005/09/28 00:00 [received]
PHST- 2005/10/31 00:00 [accepted]
PHST- 2006/02/28 09:00 [pubmed]
PHST- 2006/11/10 09:00 [medline]
PHST- 2006/02/28 09:00 [entrez]
AID - ncpcardio0407 [pii]
AID - 10.1038/ncpcardio0407 [doi]
PST - ppublish
SO  - Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S65-8. doi: 
      10.1038/ncpcardio0407.