PMID- 16501824
OWN - NLM
STAT- MEDLINE
DCOM- 20060329
LR  - 20181201
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 6
DP  - 2006 Feb 22
TI  - Inhibition of gastric acid secretion by unfractionated and low molecular weight 
      heparins in the rat.
PG  - 221-30
AB  - The majority of patients receiving heparin preparations are at stress, which is a 
      risk factor for the development of gastric erosions. Our aim was to examine the 
      effect of unfractionated heparin (UFH) and low molecular weight heparins (LMWHs) 
      on gastric acid secretion. Gastric acid secretion was induced in 
      urethane-anesthetized rats by distention of the stomach (2 ml saline for 2 h) in 
      addition to histamine or bethanechol stimulation. Distension-stimulated acid 
      secretion (2 ml for 2 h) was significantly inhibited by intraperitoneal 
      administration of UFH (2000 IU/kg, 19% reduction), enoxaparin (180 or 360 IU/kg, 
      59.2 and 87.1%, reduction, respectively), nadroparin (1000 or 2000 IU/kg, 36 and 
      60.7% reduction, respectively), and tinzaparin (3000 IU/kg, 41.3% reduction). All 
      tested heparins also suppressed acid secretion in response to distention and 
      histamine or bethanechol stimulation. Pretreatment with indomethacin did not 
      abolish the gastric inhibitory action of nadroparin. After truncal vagotomy or 
      atropine, nadroparin failed to inhibit acid secretion stimulated by histamine. 
      Ganglionic blockade with guanethidine abolished the gastric inhibitory action of 
      nadroparin or UFH. It is concluded that both UFH and LMWHs administered 
      peripherally inhibit stimulated gastric acid secretion in the rat. This effect of 
      heparins is determined by cholinergic and partly by adrenergic mechanisms.
FAU - Salam, Omar M E Abdel
AU  - Salam OM
AD  - Department of Pharmacology, National Research Centre, Dokki, Cairo. 
      omasalam@hotmail.com
FAU - Baiuomy, Ayman R
AU  - Baiuomy AR
FAU - Ameen, Amany
AU  - Ameen A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20060222
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Gastric Acid/*metabolism
MH  - Gastric Mucosa/*metabolism
MH  - Heparin, Low-Molecular-Weight/*administration & dosage
MH  - Infusions, Parenteral
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stomach/*drug effects
PMC - PMC5917260
EDAT- 2006/02/28 09:00
MHDA- 2006/03/30 09:00
PMCR- 2006/02/22
CRDT- 2006/02/28 09:00
PHST- 2006/02/28 09:00 [pubmed]
PHST- 2006/03/30 09:00 [medline]
PHST- 2006/02/28 09:00 [entrez]
PHST- 2006/02/22 00:00 [pmc-release]
AID - 537351 [pii]
AID - 10.1100/tsw.2006.42 [doi]
PST - epublish
SO  - ScientificWorldJournal. 2006 Feb 22;6:221-30. doi: 10.1100/tsw.2006.42.