PMID- 16502421
OWN - NLM
STAT- MEDLINE
DCOM- 20060908
LR  - 20131121
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 34
IP  - 2
DP  - 2006 Aug
TI  - High-dose cyclophosphamide without stem cell rescue for refractory multifocal 
      motor neuropathy.
PG  - 246-50
AB  - Patients with multifocal motor neuropathy (MMN) respond to intravenous immune 
      globulin (IVIg) and cyclophosphamide, although the benefit is not sustained. 
      High-dose cyclophosphamide can induce a remission in patients with autoimmune 
      diseases, including chronic inflammatory demyelinating polyradiculoneuropathy 
      (CIDP). We describe a patient with refractory MMN who improved with high-dose 
      cyclophosphamide (50 mg/kg for 4 days) without stem cell rescue. Following 
      treatment she discontinued IVIg. At a 6-month examination, her strength had 
      improved and she had regained the ability to write. High-dose cyclophosphamide 
      may be a successful treatment for patients with MMN refractory to other 
      therapies.
FAU - Brannagan, Thomas H 3rd
AU  - Brannagan TH 3rd
AD  - Weill Medical College of Cornell University, Department of Neurology and 
      Neuroscience, Peripheral Neuropathy Center, 635 Madison Avenue, Suite 400, New 
      York, New York 10022, USA. THB2006@med.cornell.edu
FAU - Alaedini, Armin
AU  - Alaedini A
FAU - Gladstone, Douglas E
AU  - Gladstone DE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Antineoplastic Agents)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Cyclophosphamide/*therapeutic use
MH  - Drug Resistance
MH  - Evoked Potentials, Motor/physiology
MH  - Female
MH  - Humans
MH  - Leukocyte Count
MH  - Middle Aged
MH  - Motor Neuron Disease/*drug therapy/physiopathology
MH  - Neural Conduction/physiology
MH  - Neurologic Examination
MH  - Neutrophils/physiology
MH  - Peripheral Nerves/physiopathology
EDAT- 2006/02/28 09:00
MHDA- 2006/09/09 09:00
CRDT- 2006/02/28 09:00
PHST- 2006/02/28 09:00 [pubmed]
PHST- 2006/09/09 09:00 [medline]
PHST- 2006/02/28 09:00 [entrez]
AID - 10.1002/mus.20524 [doi]
PST - ppublish
SO  - Muscle Nerve. 2006 Aug;34(2):246-50. doi: 10.1002/mus.20524.