PMID- 1650266
OWN - NLM
STAT- MEDLINE
DCOM- 19910904
LR  - 20131121
IS  - 0007-4551 (Print)
IS  - 0007-4551 (Linking)
VI  - 78
IP  - 4
DP  - 1991
TI  - [Is chemotherapy with cisplatin useful in non small cell bronchial cancer at 
      staging IV? Results of a randomized study].
PG  - 341-6
AB  - The benefit of chemotherapy for patients with disseminated non small cell lung 
      cancer (NSCLC) is controversial. The introduction of cisplatinum in the 
      combination chemotherapy for NSCLC gave rise to higher response rates. To study 
      the question of the usefulness of cisplatinum-based chemotherapy in disseminated 
      NSCLC we conducted a prospective randomized trial comparing best supportive care 
      to vindesine + cisplatin. Between December 1985 and March 1988, 49 patients with 
      stage IV NSCLC were enrolled. Of the 46 eligible patients 24 were in the 
      chemotherapy group and 22 in the best supportive care group. The treatment groups 
      were not significantly different in terms of age, performance status, histology. 
      Toxicity on the chemotherapy arm grade 3 or more was observed in 17.5% for 
      neutropenia, in 8.75% for vomiting. There was one death related to treatment. The 
      overall response rate in the chemotherapy group was 41.7%. Patients of the 
      chemotherapy group had a median survival time of 199 days and the patients of the 
      best supportive care group had a median survival time of 73 days. The difference 
      in survival is highly significant (p less than 0.001).
FAU - Quoix, E
AU  - Quoix E
AD  - Pavillon Laennec, CHRU, Strasbourg, France.
FAU - Dietemann, A
AU  - Dietemann A
FAU - Charbonneau, J
AU  - Charbonneau J
FAU - Boutin, C
AU  - Boutin C
FAU - Meurice, J C
AU  - Meurice JC
FAU - Orlando, J P
AU  - Orlando JP
FAU - Ducolone, A
AU  - Ducolone A
FAU - Pauli, G
AU  - Pauli G
FAU - Roegel, E
AU  - Roegel E
LA  - fre
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - La chimiotherapie comportant du cisplatine est-elle utile dans le cancer 
      bronchique non microcellulaire au stade IV? Resultats d'une etude randomisee.
PL  - France
TA  - Bull Cancer
JT  - Bulletin du cancer
JID - 0072416
RN  - Q20Q21Q62J (Cisplatin)
RN  - RSA8KO39WH (Vindesine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy/epidemiology/pathology
MH  - Cisplatin/administration & dosage/*therapeutic use
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*drug therapy/epidemiology/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prospective Studies
MH  - Vindesine/administration & dosage/therapeutic use
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
PST - ppublish
SO  - Bull Cancer. 1991;78(4):341-6.