PMID- 16504171
OWN - NLM
STAT- MEDLINE
DCOM- 20060424
LR  - 20181113
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 7
DP  - 2006 Feb 28
TI  - No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G 
      polymorphisms in migraine susceptibility.
PG  - 12
AB  - BACKGROUND: We have previously reported an association between the estrogen 
      receptor 1 (ESR1) gene exon 8 G594A polymorphism and migraine susceptibility in 
      two independent Australian cohorts. In this paper we report results of analysis 
      of two further single nucleotide polymorphisms (SNPs) in the ESR1 gene in the 
      same study group, the T/C Pvu II SNP in intron 1 and the C325G SNP in exon 4, as 
      well as results of linkage disequilibrium (LD) analysis on these markers. 
      METHODS: We investigated these variants by case-control association analysis in a 
      cohort of 240 migraineurs and 240 matched controls. The SNPs were genotyped using 
      specific restriction enzyme assays. Results were analysed using contingency table 
      methods incorporating the chi-squared statistic. LD results are presented as D' 
      statistics with associated P values. RESULTS: We found no evidence for 
      association of the Pvu II T/C polymorphism and the C325G polymorphism and 
      migraine susceptibility and no evidence for LD between these two SNPs and the 
      previously implicated exon 8 G594A marker. CONCLUSION: We have found no role for 
      the polymorphisms in intron 1 and exon 4 with migraine susceptibility. To further 
      investigate our previously implicated exon 8 marker, we suggest the need for 
      studies with a high density of polymorphisms be undertaken, with particular focus 
      on markers in LD with the exon 8 marker.
FAU - Colson, Natalie J
AU  - Colson NJ
AD  - Genomics Research Centre, School of Health Science, Griffith University Gold 
      Coast, PMB 50, Gold Coast Mail Centre, Queensland, 9726, Australia. 
      n.colson@griffith.edu.au
FAU - Lea, Rod A
AU  - Lea RA
FAU - Quinlan, Sharon
AU  - Quinlan S
FAU - Griffiths, Lyn R
AU  - Griffiths LR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060228
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Case-Control Studies
MH  - Estrogen Receptor alpha/*genetics
MH  - Exons
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Introns
MH  - Linkage Disequilibrium
MH  - Male
MH  - Migraine Disorders/*genetics
MH  - *Polymorphism, Single Nucleotide
PMC - PMC1431511
EDAT- 2006/03/01 09:00
MHDA- 2006/04/25 09:00
PMCR- 2006/02/28
CRDT- 2006/03/01 09:00
PHST- 2005/10/21 00:00 [received]
PHST- 2006/02/28 00:00 [accepted]
PHST- 2006/03/01 09:00 [pubmed]
PHST- 2006/04/25 09:00 [medline]
PHST- 2006/03/01 09:00 [entrez]
PHST- 2006/02/28 00:00 [pmc-release]
AID - 1471-2350-7-12 [pii]
AID - 10.1186/1471-2350-7-12 [doi]
PST - epublish
SO  - BMC Med Genet. 2006 Feb 28;7:12. doi: 10.1186/1471-2350-7-12.