PMID- 16504400
OWN - NLM
STAT- MEDLINE
DCOM- 20060510
LR  - 20161128
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 398
IP  - 1-2
DP  - 2006 May 1
TI  - Protective effect of melatonin against maternal deprivation-induced acute 
      hippocampal damage in infant rats.
PG  - 145-50
AB  - It is known that maternal deprivation induces hippocampal damage in the 
      developing brains. In the present study, we examined the effects of melatonin on 
      maternal deprivation-induced hippocampal damage both during and after 
      stress-hyporesponsive period (SHRP). Hippocampal damage was examined by cresyl 
      violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end 
      labeling (TUNEL) assay. The results showed that a single episode of maternal 
      deprivation for 24 h at post-SHRP induced neuronal loss in hippocampus regions of 
      the brain in the infant rats, while it did not influence hippocampal neurons in 
      SHRP. Melatonin prevented maternal deprivation-induced hippocampal damage in the 
      infant rats at post-SHRP. These results suggest that melatonin is a potentially 
      beneficial agent to improve the neurobehavioral outcomes of maternal deprivation 
      in later developmental period.
FAU - Tugyan, Kazim
AU  - Tugyan K
AD  - Department of Histology and Embryology, School of Medicine, Dokuz Eylul 
      University, Inciralti, 35340 Izmir, Turkey. kazim.tugyan@deu.edu.tr
FAU - Uysal, Nazan
AU  - Uysal N
FAU - Ozdemir, Durgul
AU  - Ozdemir D
FAU - Sonmez, Ulker
AU  - Sonmez U
FAU - Pekcetin, Cetin
AU  - Pekcetin C
FAU - Erbil, Guven
AU  - Erbil G
FAU - Sonmez, Atac
AU  - Sonmez A
LA  - eng
PT  - Journal Article
DEP - 20060228
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Benzoxazines)
RN  - 0 (Coloring Agents)
RN  - 0 (Oxazines)
RN  - 2AB49C465R (cresyl violet)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Benzoxazines
MH  - Coloring Agents
MH  - Female
MH  - Hippocampus/*pathology
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - *Maternal Deprivation
MH  - Melatonin/*pharmacology
MH  - Neurons/pathology
MH  - Oxazines
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/pathology/*prevention & control
EDAT- 2006/03/01 09:00
MHDA- 2006/05/11 09:00
CRDT- 2006/03/01 09:00
PHST- 2005/11/02 00:00 [received]
PHST- 2005/12/09 00:00 [revised]
PHST- 2005/12/27 00:00 [accepted]
PHST- 2006/03/01 09:00 [pubmed]
PHST- 2006/05/11 09:00 [medline]
PHST- 2006/03/01 09:00 [entrez]
AID - S0304-3940(05)01476-X [pii]
AID - 10.1016/j.neulet.2005.12.090 [doi]
PST - ppublish
SO  - Neurosci Lett. 2006 May 1;398(1-2):145-50. doi: 10.1016/j.neulet.2005.12.090. 
      Epub 2006 Feb 28.