PMID- 16504465
OWN - NLM
STAT- MEDLINE
DCOM- 20060726
LR  - 20131121
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 20
IP  - 3
DP  - 2006 May
TI  - Stress presents a problem for dendritic cells: corticosterone and the fate of MHC 
      class I antigen processing and presentation.
PG  - 210-8
AB  - Corticosterone (cortisol in humans), a glucocorticoid hormone released into 
      circulation in response to psychological stress via the 
      hypothalamic-pituitary-adrenal axis, can undermine primary and memory CD8(+) 
      cytotoxic T lymphocyte (CTL) responses. These CTL responses are vital for 
      fighting intracellular pathogens, such as viruses, and some tumors. Dendritic 
      cells (DCs) play a pivotal role in the generation of both primary and memory CTL 
      responses. DCs are specialized for antigen acquisition (by direct infection or 
      uptake from neighboring cells), transport, processing, and MHC class I-restricted 
      presentation of antigen to CTL. These are critical events that are an absolute 
      requirement for the generation of CTL responses regardless of any other immune 
      responses that may be occurring. This minireview provides an overview of the 
      components of MHC class I antigen processing and presentation pathway and 
      describes our recent published work on the effects of corticosterone on this 
      process in virally infected DCs. Corticosterone impairs the efficiency with which 
      antigen is presented on DCs. The mechanism of this impairment is shown to be via 
      a reduction in the generation of antigenic peptide from virally expressed 
      protein. This impairment of antigen processing and presentation by corticosterone 
      was also observed in non-immune cells, suggesting that stress may affect 
      essential cellular protein management functions in all cells, and having possible 
      implications for neurological or other diseases that may result from aberrant 
      protein processing.
FAU - Truckenmiller, M E
AU  - Truckenmiller ME
AD  - Department of Microbiology and Immunology, The Pennsylvania State University 
      College of Medicine, Hershey, PA 17033, USA. met11@psu.edu
FAU - Bonneau, Robert H
AU  - Bonneau RH
FAU - Norbury, Christopher C
AU  - Norbury CC
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060228
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Histocompatibility Antigens Class I)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*physiology
MH  - Cell Line
MH  - Corticosterone/*physiology
MH  - Dendritic Cells/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Stress, Physiological/*immunology
MH  - T-Lymphocytes/immunology
MH  - Virus Diseases/immunology
RF  - 36
EDAT- 2006/03/01 09:00
MHDA- 2006/07/27 09:00
CRDT- 2006/03/01 09:00
PHST- 2005/12/05 00:00 [received]
PHST- 2005/12/28 00:00 [revised]
PHST- 2006/01/07 00:00 [accepted]
PHST- 2006/03/01 09:00 [pubmed]
PHST- 2006/07/27 09:00 [medline]
PHST- 2006/03/01 09:00 [entrez]
AID - S0889-1591(06)00005-5 [pii]
AID - 10.1016/j.bbi.2006.01.002 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2006 May;20(3):210-8. doi: 10.1016/j.bbi.2006.01.002. Epub 
      2006 Feb 28.