PMID- 16504575
OWN - NLM
STAT- MEDLINE
DCOM- 20070227
LR  - 20131121
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 8
IP  - 6
DP  - 2006 Oct
TI  - A review of homocysteine and heart failure.
PG  - 571-6
AB  - Chronic heart failure (CHF) is a major public health problem causing considerable 
      morbidity and mortality. Recently, plasma homocysteine (HCY) has been suggested 
      to be increased in CHF patients potentially representing a newly recognized risk 
      marker. This manuscript reviews the existing literature regarding 
      hyperhomocysteinemia (HHCY) and CHF. Clinical data indicate that HHCY is 
      associated with an increased incidence of CHF as well as with the severity of the 
      disease. Mechanistic studies of HHCY and CHF are rare. However, preliminary 
      results suggest that HHCY causes adverse cardiac remodelling characterized by 
      interstitial and perivascular fibrosis resulting in increased myocardial 
      stiffness. In addition, HHCY seems to affect the pump function of the myocardium. 
      The mechanisms leading from an elevated HCY level to reduced pump function and 
      adverse cardiac remodelling are a matter of speculation. Existing data indicate 
      that direct effects of HCY on the myocardium as well as NO independent vascular 
      effects are involved. In conclusion, HHCY might be a potential aetiological 
      factor in CHF. Future studies need to clarify the mechanistic role of HHCY in CHF 
      as a useful paradigm with most interesting therapeutic implications, because HCY 
      lowering therapy could favourably influence the prognosis in CHF patients.
FAU - Herrmann, Markus
AU  - Herrmann M
AD  - Institut fur Klinische Chemie und Laboratoriumsmedizin/Zentrallabor, 
      Universitatsklinikum des Saarlandes, D-66421 Homburg/Saar, Germany.
FAU - Taban-Shomal, Omid
AU  - Taban-Shomal O
FAU - Hubner, Ulrich
AU  - Hubner U
FAU - Bohm, Michael
AU  - Bohm M
FAU - Herrmann, Wolfgang
AU  - Herrmann W
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060228
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Cardiac Output, Low/blood/*physiopathology
MH  - Chronic Disease
MH  - Homocysteine/*blood
MH  - Humans
MH  - Incidence
MH  - Myocardium/pathology
MH  - Risk Assessment
MH  - Risk Factors
MH  - Ventricular Remodeling/physiology
RF  - 71
EDAT- 2006/03/01 09:00
MHDA- 2007/02/28 09:00
CRDT- 2006/03/01 09:00
PHST- 2005/06/08 00:00 [received]
PHST- 2005/09/23 00:00 [revised]
PHST- 2005/11/29 00:00 [accepted]
PHST- 2006/03/01 09:00 [pubmed]
PHST- 2007/02/28 09:00 [medline]
PHST- 2006/03/01 09:00 [entrez]
AID - S1388-9842(05)00342-9 [pii]
AID - 10.1016/j.ejheart.2005.11.016 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2006 Oct;8(6):571-6. doi: 10.1016/j.ejheart.2005.11.016. Epub 
      2006 Feb 28.