PMID- 16506120
OWN - NLM
STAT- MEDLINE
DCOM- 20060526
LR  - 20060228
IS  - 0735-1631 (Print)
IS  - 0735-1631 (Linking)
VI  - 23
IP  - 2
DP  - 2006 Feb
TI  - Intravenous immunoglobulin in antiphospholipid syndrome and maternal floor 
      infarction when standard treatment fails: a case report.
PG  - 125-9
AB  - Obstetrical antiphospholipid syndrome (APS) is associated with maternal and fetal 
      morbidity and mortality. Standard treatment with low-dose acetylsalicylic acid 
      and unfractionated heparin has achieved up to a 70 to 80% likelihood of success. 
      Conversely, up to 30% of women with APS will have further pregnancy losses, 
      despite treatment. Intravenous immunoglobulin (IVIG) may be a promising adjuvant 
      when standard treatment fails. We present a case of a 35-year-old woman with 
      obstetrical APS and maternal floor infarction in prior pregnancy losses who 
      continued to have further unsuccessful pregnancies despite standard treatment 
      with acetylsalicylic acid and unfractionated heparin. On an investigational 
      basis, she was prescribed concomitant IVIG and had two subsequent healthy 
      newborns. IVIG appears to be promising in obstetrical patients with APS who are 
      refractory to standard treatment. Prior history of maternal floor infarction may 
      be a prognostic indicator for triple therapy for obstetrical APS.
FAU - Chang, Phyllis
AU  - Chang P
AD  - Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois 
      60637, USA.
FAU - Millar, Debra
AU  - Millar D
FAU - Tsang, Peter
AU  - Tsang P
FAU - Lim, Kenneth
AU  - Lim K
FAU - Houlihan, Edwina
AU  - Houlihan E
FAU - Stephenson, Mary
AU  - Stephenson M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Perinatol
JT  - American journal of perinatology
JID - 8405212
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Adult
MH  - Antiphospholipid Syndrome/diagnosis/*drug therapy
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Female
MH  - Follow-Up Studies
MH  - Gestational Age
MH  - Humans
MH  - Immunoglobulins, Intravenous/*administration & dosage
MH  - Infarction/*diagnosis/drug therapy
MH  - Maternal Age
MH  - Parity
MH  - Pelvic Floor/*blood supply
MH  - Pregnancy
MH  - Pregnancy Complications/diagnosis/*drug therapy
MH  - *Pregnancy Outcome
MH  - Prenatal Care/methods
MH  - Risk Assessment
MH  - Treatment Outcome
RF  - 14
EDAT- 2006/03/01 09:00
MHDA- 2006/05/27 09:00
CRDT- 2006/03/01 09:00
PHST- 2006/03/01 09:00 [pubmed]
PHST- 2006/05/27 09:00 [medline]
PHST- 2006/03/01 09:00 [entrez]
AID - 10.1055/s-2006-931805 [doi]
PST - ppublish
SO  - Am J Perinatol. 2006 Feb;23(2):125-9. doi: 10.1055/s-2006-931805.