PMID- 16506178
OWN - NLM
STAT- MEDLINE
DCOM- 20060731
LR  - 20200930
IS  - 1552-4973 (Print)
IS  - 1552-4973 (Linking)
VI  - 77
IP  - 2
DP  - 2006 May
TI  - In vitro and in vivo release of gentamicin from biodegradable discs.
PG  - 329-37
AB  - Osteomyelitis is an infection of the bone and successful treatment involves the 
      removal of the affected bone and the tissue by a surgical procedure following 
      prolonged systemic and local antibiotic therapy for 4 to 6 weeks. The current 
      local treatment is done by poly methyl methacrylate (PMMA) beads loaded with 
      gentamicin and PMMA, being nondegradable, is to be removed by a second surgical 
      procedure. The current study aims to develop a biodegradable composition that 
      gives sustained release and hence reducing the need for a second surgery. 
      Gentamicin-loaded discs were produced by compressing microparticle-gentamicin 
      mixture obtained by spray drying a mixture of gentamicin in a solution of a 
      biodegradable polymer. Different copolymers of poly (DL-lactic-co-glycolic acid) 
      (PLGA) were used to study the effect of copolymer ratio and the 
      hydrophilic-hydrophobic nature of the polymer. Theoretical drug loading up to 25% 
      were studied and it was observed that 10% drug loading was optimum for gentamicin 
      to be used as solid in spray drying. The results showed that about 60% of the 
      drug is released in about 5 to 6 days and the remaining drug is released in about 
      30 days in total. An in vivo study was carried on rabbit femur and the local area 
      and systemic concentration of gentamicin was monitored. It was observed that the 
      local area concentration of gentamicin was above minimum inhibitory concentration 
      for more than 20 days and this was also validated by computer simulations.
CI  - (c) 2006 Wiley Periodicals, Inc.
FAU - Naraharisetti, Pavan Kumar
AU  - Naraharisetti PK
AD  - Department of Chemical and Biomolecular Engineering, National University of 
      Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore.
FAU - Guan Lee, Herman Chian
AU  - Guan Lee HC
FAU - Fu, Yin-Chih
AU  - Fu YC
FAU - Lee, Duu-Jong
AU  - Lee DJ
FAU - Wang, Chi-Hwa
AU  - Wang CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Gentamicins)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Animals
MH  - Biodegradation, Environmental
MH  - Delayed-Action Preparations/*chemistry
MH  - Femur
MH  - Gentamicins/*administration & dosage
MH  - Kinetics
MH  - Lactic Acid/therapeutic use
MH  - Osteomyelitis/drug therapy
MH  - Polyglycolic Acid/therapeutic use
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/therapeutic use
MH  - Rabbits
EDAT- 2006/03/01 09:00
MHDA- 2006/08/01 09:00
CRDT- 2006/03/01 09:00
PHST- 2006/03/01 09:00 [pubmed]
PHST- 2006/08/01 09:00 [medline]
PHST- 2006/03/01 09:00 [entrez]
AID - 10.1002/jbm.b.30374 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2006 May;77(2):329-37. doi: 
      10.1002/jbm.b.30374.