PMID- 16506215
OWN - NLM
STAT- MEDLINE
DCOM- 20060728
LR  - 20220409
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 119
IP  - 3
DP  - 2006 Aug 1
TI  - Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, 
      lung and colorectum.
PG  - 695-701
AB  - There is increasing epidemiological evidence for a role of allergic/atopic 
      disorders in cancer development. However, findings have been inconsistent, which 
      may be partly due to differences in defining allergy and the associated atopic 
      disorders. The use of a biological marker for atopy may enhance the exploration 
      of the association with cancer risks. To examine the association of atopy with 
      common malignancies, we compared the prevalence of atopy in 318 patients with 
      prostate cancer, 381 patients with breast cancer, 196 patients with lung cancer, 
      477 patients with colorectal cancer and 4,271 controls in a case-control analysis 
      of participants of 2 prospective studies conducted in Saarland, Germany. Data on 
      physician-diagnosed atopy-related diseases (asthma, hay fever and atopic 
      dermatitis) were obtained by self-administered questionnaire. Allergen-specific 
      immunoglobulin E (IgE) was assessed among cases and controls to define atopy. We 
      observed a significantly increased risk of prostate cancer (odds ratio (OR) 1.35, 
      95% confidence interval (CI) 1.00-1.83) and a tentatively, statistically not 
      significant increased risk of breast cancer (OR 1.20, 95% CI 0.87-1.66) and lung 
      cancer (OR 1.29, 95% CI 0.87-1.92) with specific IgE positivity. No consistent 
      associations were found with atopy-related diseases. Our findings are consistent 
      with other epidemiological evidence suggesting an increased risk of prostate 
      cancer with atopy and indicate a complex association between atopy/atopy-related 
      diseases and cancer risk that varies by type of atopy-related disorders and the 
      particular type of cancer under consideration. The effect on cancer risk by 
      atopy, defined by IgE reactivity, may differ from the effect by atopy-related 
      clinically defined diseases such as asthma, hay fever and atopic dermatitis.
CI  - Copyright (c) 2006 Wiley-Liss, Inc.
FAU - Wang, Hao
AU  - Wang H
AD  - Department of Clinical Social Medicine, University of Heidelberg, and Unit of 
      Health Monitoring, Saarland Cancer Registry, Saarbrucken, Germany.
FAU - Rothenbacher, Dietrich
AU  - Rothenbacher D
FAU - Low, Michael
AU  - Low M
FAU - Stegmaier, Christa
AU  - Stegmaier C
FAU - Brenner, Hermann
AU  - Brenner H
FAU - Diepgen, Thomas L
AU  - Diepgen TL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aged
MH  - Alcohol Drinking
MH  - Breast Neoplasms/epidemiology/etiology
MH  - Case-Control Studies
MH  - Colorectal Neoplasms/epidemiology/etiology
MH  - Confidence Intervals
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Hypersensitivity, Immediate/*complications/immunology
MH  - Immunoglobulin E/*blood
MH  - Logistic Models
MH  - Lung Neoplasms/epidemiology/etiology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*epidemiology/etiology
MH  - Odds Ratio
MH  - Prevalence
MH  - Prostatic Neoplasms/epidemiology/etiology
MH  - Risk Factors
MH  - Smoking
MH  - Surveys and Questionnaires
EDAT- 2006/03/01 09:00
MHDA- 2006/07/29 09:00
CRDT- 2006/03/01 09:00
PHST- 2006/03/01 09:00 [pubmed]
PHST- 2006/07/29 09:00 [medline]
PHST- 2006/03/01 09:00 [entrez]
AID - 10.1002/ijc.21883 [doi]
PST - ppublish
SO  - Int J Cancer. 2006 Aug 1;119(3):695-701. doi: 10.1002/ijc.21883.