PMID- 16508761
OWN - NLM
STAT- MEDLINE
DCOM- 20070302
LR  - 20181113
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 189
IP  - 4
DP  - 2007 Jan
TI  - Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves 
      contextual processing of visuospatial information unaffected.
PG  - 557-63
AB  - RATIONALE: Research concerning spatial memory in 
      3,4-methylenedioxymethamphetamine (MDMA) users has presented conflicting results 
      showing either the presence or absence of spatial memory deficits. Two factors 
      may have confounded results in abstinent users: memory task characteristics and 
      polydrug use. OBJECTIVES: The present study aims to assess whether a single dose 
      of MDMA affects spatial memory performance during intoxication and withdrawal 
      phase and whether spatial memory performance after MDMA is task dependent. 
      MATERIALS AND METHODS: Eighteen recreational MDMA users participated in a 
      double-blind, placebo-controlled, three-way crossover design. They were treated 
      with placebo, MDMA 75 mg, and methylphenidate 20 mg. Memory tests were conducted 
      between 1.5 and 2 h (intoxication phase) and between 25.5 and 26 h (withdrawal 
      phase) post-dosing. Two spatial memory tasks of varying complexity were used that 
      required either storage of stimulus location alone (spatial memory task) or 
      memory for location as well as processing of content or contextual information 
      (change blindness task). RESULTS: After a single dose of MDMA, the subjects made 
      larger localization errors and responded faster compared to placebo in the simple 
      spatial memory task during intoxication phase. Inaccuracy was not due to 
      increased response speed, as determined by regression analysis. Performance in 
      the change blindness task was not affected by MDMA. Methylphenidate did not 
      affect performance on any of the tasks. CONCLUSION: It is concluded that a single 
      dose of MDMA impairs spatial memory for location but leaves processing of 
      contextual information intact.
FAU - Kuypers, Kim P C
AU  - Kuypers KP
AD  - Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of 
      Psychology, Maastricht University, Maastricht, The Netherlands. 
      k.kuypers@psychology.unimaas.nl
FAU - Ramaekers, Johannes G
AU  - Ramaekers JG
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060301
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Female
MH  - Hallucinogens/blood/pharmacokinetics/*pharmacology
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Memory/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/blood/pharmacokinetics/*pharmacology
MH  - Reaction Time/drug effects
MH  - Space Perception/*drug effects
EDAT- 2006/03/02 09:00
MHDA- 2007/03/03 09:00
CRDT- 2006/03/02 09:00
PHST- 2005/11/04 00:00 [received]
PHST- 2006/01/09 00:00 [accepted]
PHST- 2006/03/02 09:00 [pubmed]
PHST- 2007/03/03 09:00 [medline]
PHST- 2006/03/02 09:00 [entrez]
AID - 10.1007/s00213-006-0321-7 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2007 Jan;189(4):557-63. doi: 
      10.1007/s00213-006-0321-7. Epub 2006 Mar 1.