PMID- 16509868
OWN - NLM
STAT- MEDLINE
DCOM- 20060801
LR  - 20111117
IS  - 0815-9319 (Print)
IS  - 0815-9319 (Linking)
VI  - 21
IP  - 2
DP  - 2006 Feb
TI  - HLA-DQB1 locus and gastric cancer in Helicobacter pylori infection.
PG  - 420-4
AB  - BACKGROUND AND AIMS: It has been suggested that the incidence of digestive 
      diseases associated with Helicobacter pylori is influenced by the strain 
      diversity of H. pylori, factors involving the host or environment, and the 
      duration of infection. The authors have previously reported that human leukocyte 
      antigen (HLA)-DQB1*0401 plays an important role in the development of atrophic 
      gastritis in H. pylori infected patients. The aim of the present study was to 
      investigate the relationship between HLA-DQB1 genotype and cancer development. 
      METHODS: HLA-DQB1 genotyping was performed by the PCR-RFLP method on 122 H. 
      pylori-infected non-ulcer dyspepsia (NUD) patients, 53 gastric cancer patients 
      and 28 uninfected controls. To reliably estimate the grade of atrophic gastritis, 
      histological evaluation was performed. RESULTS: The allele frequency of DQB1*0401 
      was significantly higher in intestinal type cancer patients compared with age- 
      and sex-matched H. pylori-infected NUD patients. There was no significant 
      difference in the mean atrophic scores of the biopsy samples from the lesser 
      curvature of the mid-corpus between these groups. CONCLUSIONS: HLA-DQB1*0401 is a 
      useful marker for determining susceptibility to intestinal type gastric cancer.
FAU - Watanabe, Yoshinori
AU  - Watanabe Y
AD  - Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical 
      Molecular Medicine, Kobe University School of Medicine, Kobe, Japan.
FAU - Aoyama, Nobuo
AU  - Aoyama N
FAU - Sakai, Toshiyuki
AU  - Sakai T
FAU - Shirasaka, Daisuke
AU  - Shirasaka D
FAU - Maekawa, Shuji
AU  - Maekawa S
FAU - Kuroda, Kohei
AU  - Kuroda K
FAU - Wambura, Casmir
AU  - Wambura C
FAU - Tamura, Takao
AU  - Tamura T
FAU - Nose, Yoshisuke
AU  - Nose Y
FAU - Kasuga, Masato
AU  - Kasuga M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adenocarcinoma/complications/*genetics/pathology
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Antibodies, Bacterial/analysis
MH  - Biopsy
MH  - DNA/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Helicobacter Infections/*genetics/microbiology/pathology
MH  - Helicobacter pylori/immunology/*isolation & purification
MH  - Humans
MH  - *Locus Control Region
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - Stomach Neoplasms/complications/*genetics/pathology
EDAT- 2006/03/03 09:00
MHDA- 2006/08/02 09:00
CRDT- 2006/03/03 09:00
PHST- 2006/03/03 09:00 [pubmed]
PHST- 2006/08/02 09:00 [medline]
PHST- 2006/03/03 09:00 [entrez]
AID - JGH [pii]
AID - 10.1111/j.1440-1746.2005.04112.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2006 Feb;21(2):420-4. doi: 
      10.1111/j.1440-1746.2005.04112.x.