PMID- 16510092
OWN - NLM
STAT- MEDLINE
DCOM- 20060424
LR  - 20190823
IS  - 0025-7753 (Print)
IS  - 0025-7753 (Linking)
VI  - 126
IP  - 6
DP  - 2006 Feb 18
TI  - [Use of betablockers in elderly patients with congestive heart failure].
PG  - 206-10
AB  - BACKGROUND AND OBJECTIVE: Few studies of betablockers (BB) have been performed 
      specifically in older patients with congestive heart failure (CHF). We evaluated 
      the characteristics of elderly patients with CHF treated with BB. Moreover, we 
      assessed whether BB are associated with a better outcome in them. PATIENTS AND 
      METHOD: We evaluated clinical and functional characteristics of patients aged > 
      or = 75 years with CHF treated with or without BB, with special interest being 
      paid in the mortality. RESULTS: 47 out of 107 patients were treated with BB. Only 
      in 3 it was necessary to withdraw BB. Patients treated with no BB were older, 
      with a higher New York Heart Association (NYHA) class, more prevalent chronic 
      obstructive pulmonary disease (COPD) and in poorer functional situation. In 
      patients treated with BB, ischemic heart disease was more prevalent. Reasons for 
      "no treatment with BB" were severe aortic stenosis (n = 2), severe mitral 
      regurgitation (n = 9), asthma-COPD (n = 28), arterial disease (n = 16) and 
      fragility (n = 9). 25% of the patients on BB reached the target dose. One-year 
      mortality (5.7% vs 27.6%) and 2-year mortality (20.68% vs 60%) were both 
      significantly lower (p = 0.01 and p = 0.002, respectively) in patients on BB. 
      CONCLUSIONS: 44% of our elderly patients with CHF received BB with good 
      tolerance. Patients treated with BB were younger, with more ischemic heart 
      disease, better NYHA class, less functional deterioration and without COPD. 
      One-year and two-year mortality in patients who can receive BB were lower.
FAU - Urrutia, Agustin
AU  - Urrutia A
AD  - Unidad de Insuficiencia Cardiaca, Hospital Universitari Germans Trias i Pujol, 
      Universitat Autonoma de Barcelona, Badalona, Barcelona, Spain. 
      aurrutia@ns.hugtip.scs.es
FAU - Lupon, Josep
AU  - Lupon J
FAU - Altimir, Salvador
AU  - Altimir S
FAU - Gonzalez, Beatriz
AU  - Gonzalez B
FAU - Herreros, Joan
AU  - Herreros J
FAU - Diez, Crisanto
AU  - Diez C
FAU - Coll, Ramon
AU  - Coll R
FAU - Valle, Vicente
AU  - Valle V
FAU - Rey-Joly, Celestino
AU  - Rey-Joly C
LA  - spa
PT  - Comparative Study
PT  - Journal Article
TT  - Uso de bloqueadores beta en pacientes ancianos con insuficiencia cardiaca.
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Carbazoles)
RN  - 0 (Propanolamines)
RN  - 0 (Vasodilator Agents)
RN  - 0K47UL67F2 (Carvedilol)
RN  - GEB06NHM23 (Metoprolol)
RN  - Y41JS2NL6U (Bisoprolol)
SB  - IM
MH  - Adrenergic beta-Antagonists/*therapeutic use
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Antihypertensive Agents/administration & dosage/therapeutic use
MH  - Bisoprolol/administration & dosage/therapeutic use
MH  - Carbazoles/administration & dosage/therapeutic use
MH  - Carvedilol
MH  - Data Interpretation, Statistical
MH  - Female
MH  - Heart Failure/complications/*drug therapy/mortality
MH  - Humans
MH  - Male
MH  - Metoprolol/administration & dosage/therapeutic use
MH  - Propanolamines/administration & dosage/therapeutic use
MH  - Risk Factors
MH  - Survival Analysis
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vasodilator Agents/administration & dosage/therapeutic use
EDAT- 2006/03/03 09:00
MHDA- 2006/04/25 09:00
CRDT- 2006/03/03 09:00
PHST- 2006/03/03 09:00 [pubmed]
PHST- 2006/04/25 09:00 [medline]
PHST- 2006/03/03 09:00 [entrez]
AID - S0025-7753(06)71883-8 [pii]
AID - 10.1157/13084869 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2006 Feb 18;126(6):206-10. doi: 10.1157/13084869.