PMID- 16510593
OWN - NLM
STAT- MEDLINE
DCOM- 20060418
LR  - 20240104
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 66
IP  - 5
DP  - 2006 Mar 1
TI  - Hypoxia-inducible factor-1-dependent repression of E-cadherin in von 
      Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, 
      ZFHX1A, and ZFHX1B.
PG  - 2725-31
AB  - A critical event in the pathogenesis of invasive and metastatic cancer is 
      E-cadherin loss of function. Renal clear cell carcinoma (RCC) is characterized by 
      loss of function of the von Hippel-Lindau tumor suppressor (VHL), which 
      negatively regulates hypoxia-inducible factor-1 (HIF-1). Loss of E-cadherin 
      expression and decreased cell-cell adhesion in VHL-null RCC4 cells were corrected 
      by enforced expression of VHL, a dominant-negative HIF-1alpha mutant, or a short 
      hairpin RNA directed against HIF-1alpha. In human RCC biopsies, expression of 
      E-cadherin and HIF-1alpha was mutually exclusive. The expression of mRNAs 
      encoding TCF3, ZFHX1A, and ZFHX1B, which repress E-cadherin gene transcription, 
      was increased in VHL-null RCC4 cells in a HIF-1-dependent manner. Thus, HIF-1 
      contributes to the epithelial-mesenchymal transition in VHL-null RCC by indirect 
      repression of E-cadherin.
FAU - Krishnamachary, Balaji
AU  - Krishnamachary B
AD  - Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins 
      University School of Medicine, Baltimore, Maryland 21205, USA.
FAU - Zagzag, David
AU  - Zagzag D
FAU - Nagasawa, Hideko
AU  - Nagasawa H
FAU - Rainey, Karin
AU  - Rainey K
FAU - Okuyama, Hiroaki
AU  - Okuyama H
FAU - Baek, Jin H
AU  - Baek JH
FAU - Semenza, Gregg L
AU  - Semenza GL
LA  - eng
GR  - P50-CA103175/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Cadherins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Repressor Proteins)
RN  - 0 (TCF3 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (ZEB1 protein, human)
RN  - 0 (ZEB2 protein, human)
RN  - 0 (Zinc Finger E-box Binding Homeobox 2)
RN  - 0 (Zinc Finger E-box-Binding Homeobox 1)
RN  - EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein)
SB  - IM
MH  - Basic Helix-Loop-Helix Transcription Factors/biosynthesis/genetics/*physiology
MH  - Biopsy
MH  - Cadherins/*biosynthesis/genetics
MH  - Carcinoma, Renal Cell/genetics/*metabolism/pathology
MH  - Cell Adhesion/physiology
MH  - Down-Regulation
MH  - Epithelial Cells/pathology
MH  - Gene Expression Regulation, Neoplastic
MH  - Homeodomain Proteins/biosynthesis/genetics/*physiology
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/biosynthesis/genetics/*physiology
MH  - Immunohistochemistry
MH  - Kidney Neoplasms/genetics/*metabolism/pathology
MH  - Mesoderm/pathology
MH  - RNA, Messenger/biosynthesis/genetics
MH  - RNA, Small Interfering/genetics
MH  - Repressor Proteins/biosynthesis/genetics/*physiology
MH  - Transcription Factors/biosynthesis/genetics/*physiology
MH  - Transcription, Genetic
MH  - Von Hippel-Lindau Tumor Suppressor Protein/biosynthesis/genetics/*physiology
MH  - Zinc Finger E-box Binding Homeobox 2
MH  - Zinc Finger E-box-Binding Homeobox 1
EDAT- 2006/03/03 09:00
MHDA- 2006/04/19 09:00
CRDT- 2006/03/03 09:00
PHST- 2006/03/03 09:00 [pubmed]
PHST- 2006/04/19 09:00 [medline]
PHST- 2006/03/03 09:00 [entrez]
AID - 66/5/2725 [pii]
AID - 10.1158/0008-5472.CAN-05-3719 [doi]
PST - ppublish
SO  - Cancer Res. 2006 Mar 1;66(5):2725-31. doi: 10.1158/0008-5472.CAN-05-3719.