PMID- 16511245
OWN - NLM
STAT- MEDLINE
DCOM- 20060602
LR  - 20240322
IS  - 1744-3091 (Electronic)
IS  - 1744-3091 (Linking)
VI  - 61
IP  - Pt 12
DP  - 2005 Dec 1
TI  - X-ray diffraction analysis of crystals from the human major histocompatibility 
      antigen HLA-B*2706 in complex with a viral peptide and with a self-peptide.
PG  - 1097-9
AB  - The human leukocyte antigen (HLA) alleles HLA-B*2704 and HLA-B*2706 show an 
      ethnically restricted distribution and are differentially associated with 
      ankylosing spondylitis, with HLA-B*2706 lacking association with this autoimmune 
      disease. However, the products of the two alleles differ by only two amino acids, 
      at heavy-chain residues 114 (His in HLA-B*2704; Asp in HLA-B*2706) and 116 (Asp 
      in HLA-B*2704; Tyr in HLA-B*2706). Both residues could be involved in contacting 
      amino acids of a bound peptide, suggesting that peptides presented by these 
      subtypes play a role in disease pathogenesis. Two HLA-B*2706-peptide complexes 
      were crystallized using the hanging-drop vapour-diffusion method with PEG as 
      precipitant. Data sets were collected to resolutions of 2.70 A (viral peptide 
      pLMP2, RRRWRRLTV; space group P2(1)2(1)2(1)) and 1.83 A (self-peptide pVIPR, 
      RRKWRRWHL; space group P2(1)). Using HLA-B*2705 complexed with the pGR peptide 
      (RRRWHRWRL) as a search model, unambiguous molecular-replacement solutions were 
      found for both HLA-B*2706 complexes.
FAU - Zawacka, Anna
AU  - Zawacka A
AD  - Institut fur Immungenetik, Charite-Universitatsmedizin Berlin, Campus 
      Virchow-Klinikum, Humboldt-Universitat zu Berlin, Spandauer Damm 130, 14050 
      Berlin, Germany.
FAU - Loll, Bernhard
AU  - Loll B
FAU - Biesiadka, Jacek
AU  - Biesiadka J
FAU - Saenger, Wolfram
AU  - Saenger W
FAU - Uchanska-Ziegler, Barbara
AU  - Uchanska-Ziegler B
FAU - Ziegler, Andreas
AU  - Ziegler A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051124
PL  - England
TA  - Acta Crystallogr Sect F Struct Biol Cryst Commun
JT  - Acta crystallographica. Section F, Structural biology and crystallization 
      communications
JID - 101226117
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*27:06 antigen)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Peptides)
RN  - 0 (Viral Proteins)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - Crystallization
MH  - HLA-B Antigens/*chemistry
MH  - HLA-B27 Antigen
MH  - Humans
MH  - Peptides/chemistry
MH  - Polyethylene Glycols/chemistry
MH  - Spondylitis, Ankylosing/metabolism
MH  - Viral Proteins/chemistry
MH  - X-Ray Diffraction
PMC - PMC1978159
EDAT- 2006/03/03 09:00
MHDA- 2006/06/03 09:00
PMCR- 2007/12/01
CRDT- 2006/03/03 09:00
PHST- 2005/11/01 00:00 [received]
PHST- 2005/11/17 00:00 [accepted]
PHST- 2006/03/03 09:00 [pubmed]
PHST- 2006/06/03 09:00 [medline]
PHST- 2006/03/03 09:00 [entrez]
PHST- 2007/12/01 00:00 [pmc-release]
AID - S1744309105037966 [pii]
AID - en5140 [pii]
AID - 10.1107/S1744309105037966 [doi]
PST - ppublish
SO  - Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Dec 1;61(Pt 12):1097-9. 
      doi: 10.1107/S1744309105037966. Epub 2005 Nov 24.