PMID- 16513373
OWN - NLM
STAT- MEDLINE
DCOM- 20070220
LR  - 20191210
IS  - 1063-4584 (Print)
IS  - 1063-4584 (Linking)
VI  - 14
IP  - 7
DP  - 2006 Jul
TI  - Predictors for response to rehabilitation in patients with hip or knee 
      osteoarthritis: a comparison of logistic regression models with three different 
      definitions of responder.
PG  - 641-51
AB  - OBJECTIVE: To identify pre-treatment predictors of who will benefit from a 
      3-4-week comprehensive rehabilitation intervention in patients with 
      osteoarthritis (OA) of the knee or hip. METHODS: A prospective cohort study with 
      assessments at admission to the clinic and after 6 months was conducted. Two 
      hundred and fifty patients from the rehabilitation clinic Rehaclinic Zurzach, 
      Switzerland, were included. Three different measures of response to a 3-4-week 
      comprehensive rehabilitation intervention were used: one indirect measure 
      (minimal clinically important difference (MCID) in the Western Ontario and 
      McMaster Universities Osteoarthritis Index (WOMAC) global score=18% improvement), 
      one direct measure (transition question) and a combination of both criteria. 
      Responders were predicted by a sequential logistic regression analysis with nine 
      personal variables, five lifestyle risk factors, seven psychological status 
      variables and the WOMAC global baseline score. RESULTS: The set of statistically 
      significant predictors was dependent on the definition of response. The 
      comparison of predictors that were statistically significant in any of the 
      prediction models showed similar odds ratios (ORs) for the majority of predictors 
      across three regression models with the different response definitions as 
      dependent variable. Female gender, absence of depressive symptoms (dep), history 
      of complementary medicine (cm) and low comorbidity (com) were the most stable 
      predictors and had ORs above 2.0 (female) and above 1.5 (dep, cm, com) across the 
      three regression models with different response definitions. CONCLUSION: A set of 
      predictors for the outcome of rehabilitation in patients with OA was identified. 
      If these predictors could be confirmed in future research, this knowledge might 
      help to adopt and individualize the treatment of patients who are, at present, 
      less likely to respond.
FAU - Weigl, M
AU  - Weigl M
AD  - Department of Physical Medicine and Rehabilitation, University Hospital Munich, 
      Marchioninistrasse 15, 81377 Munich, Germany.
FAU - Angst, F
AU  - Angst F
FAU - Aeschlimann, A
AU  - Aeschlimann A
FAU - Lehmann, S
AU  - Lehmann S
FAU - Stucki, G
AU  - Stucki G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060228
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
SB  - IM
MH  - Aged
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Hip/epidemiology/*rehabilitation
MH  - Osteoarthritis, Knee/epidemiology/*rehabilitation
MH  - Outcome Assessment, Health Care
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Risk Factors
MH  - Switzerland/epidemiology
EDAT- 2006/03/04 09:00
MHDA- 2007/02/21 09:00
CRDT- 2006/03/04 09:00
PHST- 2005/06/23 00:00 [received]
PHST- 2006/01/03 00:00 [accepted]
PHST- 2006/03/04 09:00 [pubmed]
PHST- 2007/02/21 09:00 [medline]
PHST- 2006/03/04 09:00 [entrez]
AID - S1063-4584(06)00002-1 [pii]
AID - 10.1016/j.joca.2006.01.001 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2006 Jul;14(7):641-51. doi: 10.1016/j.joca.2006.01.001. 
      Epub 2006 Feb 28.