PMID- 16514313 OWN - NLM STAT- MEDLINE DCOM- 20060705 LR - 20091119 IS - 0269-9370 (Print) IS - 0269-9370 (Linking) VI - 20 IP - 5 DP - 2006 Mar 21 TI - Tracing the origin of Brazilian HTLV-1 as determined by analysis of host and viral genes. PG - 780-2 AB - We compared the genetic diversity of the Brazilian human T-cell lymphotropic virus type 1 isolates with those found in KwaZulu-Natal (KZN), South Africa, and with the genetic background of the hosts. The seroprevalence rate in KZN was 1.7%. All sequences belonged to the A subgroup. The presence of South African sequences in two different clusters from Brazil, and the finding of the beta-globin haplotype in infected hosts are consistent with the transmission of this virus from southern Africa to Brazil. FAU - Alcantara, Luiz C J AU - Alcantara LC AD - Public Health Advanced Laboratory, Goncalo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil. FAU - de Oliveira, Tulio AU - de Oliveira T FAU - Gordon, Michelle AU - Gordon M FAU - Pybus, Oliver AU - Pybus O FAU - Mascarenhas, Rita Elizabeth AU - Mascarenhas RE FAU - Seixas, Magda O AU - Seixas MO FAU - Goncalves, Marilda AU - Goncalves M FAU - Hlela, Carol AU - Hlela C FAU - Cassol, Sharon AU - Cassol S FAU - Galvao-Castro, Bernardo AU - Galvao-Castro B LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - AIDS JT - AIDS (London, England) JID - 8710219 RN - 9004-22-2 (Globins) SB - IM MH - Brazil/epidemiology MH - *Evolution, Molecular MH - *Genes, Viral MH - Genetic Variation MH - Globins/genetics MH - HTLV-I Infections/epidemiology/*genetics MH - Haplotypes MH - Human T-lymphotropic virus 1/*genetics MH - Humans MH - Molecular Epidemiology/methods MH - Phylogeny MH - Seroepidemiologic Studies MH - South Africa MH - Terminal Repeat Sequences EDAT- 2006/03/04 09:00 MHDA- 2006/07/06 09:00 CRDT- 2006/03/04 09:00 PHST- 2006/03/04 09:00 [pubmed] PHST- 2006/07/06 09:00 [medline] PHST- 2006/03/04 09:00 [entrez] AID - 00002030-200603210-00022 [pii] AID - 10.1097/01.aids.0000216383.14808.13 [doi] PST - ppublish SO - AIDS. 2006 Mar 21;20(5):780-2. doi: 10.1097/01.aids.0000216383.14808.13.