PMID- 16516415
OWN - NLM
STAT- MEDLINE
DCOM- 20060804
LR  - 20161124
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 165
IP  - 1
DP  - 2006 Aug 1
TI  - Developmental toxic effects of diisobutyl phthalate, the methyl-branched analogue 
      of di-n-butyl phthalate, administered by gavage to rats.
PG  - 39-46
AB  - The developmental toxicity of diisobutyl phthalate (DIBP) was studied in 
      Sprague-Dawley rats after oral administration. Pregnant rats were given DIBP at 
      doses of 0 (olive oil), 250, 500, 750, and 1000 mg/kg/day, by gavage (5 ml/kg), 
      on gestational days (GD) 6 through 20. Maternal toxicity, as evidenced by 
      reduction in body weight gain, was observed at the beginning of treatment (GD 
      6-9), at 500 mg/kg and higher doses. The incidence of resorptions was 
      significantly increased at 750 mg/kg, and reached 60% at 1000 mg/kg. There was a 
      dose-related decrease in fetal weight, which was significantly lower than control 
      from 500 mg/kg. A significant increase in the incidence of fetuses with visceral 
      and skeletal malformations was seen at 750 and 1000 mg/kg. In particular, fused 
      sternebrae occurred at a significantly higher frequency. Two skeletal variations 
      were increased at 750 and 1000 mg/kg: retarded ossification of vertebrae, and 
      predominantly, supernumerary ribs. The incidence of male fetuses with undescended 
      testes was also significantly elevated at the two highest doses. In conclusion, 
      DIBP administered by gavage is embryotoxic and teratogenic, and affects the 
      developing male reproductive tract, at maternal toxic doses.
FAU - Saillenfait, A M
AU  - Saillenfait AM
AD  - Institut National de Recherche et de Securite, Avenue de Bourgogne, B.P. No. 27, 
      54501 Vandoeuvre, France. anne-marie.saillenfait@inrs.fr
FAU - Sabate, J P
AU  - Sabate JP
FAU - Gallissot, F
AU  - Gallissot F
LA  - eng
PT  - Journal Article
DEP - 20060303
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Plasticizers)
RN  - 2286E5R2KE (Dibutyl Phthalate)
RN  - IZ67FTN290 (diisobutyl phthalate)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Congenital Abnormalities/*etiology
MH  - Dibutyl Phthalate/*analogs & derivatives/chemistry/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Fetal Resorption/*chemically induced
MH  - Gestational Age
MH  - Isomerism
MH  - Male
MH  - Plasticizers/chemistry/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Toxicity Tests, Chronic
EDAT- 2006/03/07 09:00
MHDA- 2006/08/05 09:00
CRDT- 2006/03/07 09:00
PHST- 2005/11/09 00:00 [received]
PHST- 2006/01/24 00:00 [revised]
PHST- 2006/01/24 00:00 [accepted]
PHST- 2006/03/07 09:00 [pubmed]
PHST- 2006/08/05 09:00 [medline]
PHST- 2006/03/07 09:00 [entrez]
AID - S0378-4274(06)00022-1 [pii]
AID - 10.1016/j.toxlet.2006.01.013 [doi]
PST - ppublish
SO  - Toxicol Lett. 2006 Aug 1;165(1):39-46. doi: 10.1016/j.toxlet.2006.01.013. Epub 
      2006 Mar 3.