PMID- 16516994
OWN - NLM
STAT- MEDLINE
DCOM- 20060713
LR  - 20091119
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 55
IP  - 1
DP  - 2006 May
TI  - BDNF in sensory neurons and chronic pain.
PG  - 1-10
AB  - Neurotrophic factors, which support neuronal survival and growth during 
      development of the nervous system, have been shown to play significant roles in 
      the transmission of physiologic and pathologic pain. Brain-derived neurotrophic 
      factor (BDNF), synthesized in the primary sensory neurons, is anterogradely 
      transported to the central terminals of the primary afferents in the spinal 
      dorsal horn, where it is involved in the modulation of painful stimuli. In models 
      of inflammatory and neuropathic pain, BDNF synthesis is greatly increased in 
      different populations of dorsal root ganglion (DRG) neurons. Furthermore, it is 
      now known that the activation of mitogen-activated protein kinases occurs in 
      these sensory neurons and contributes to persistent inflammatory and neuropathic 
      pain by regulating BDNF expression. The recent discovery that BDNF upregulation 
      in the DRG and spinal cord contributes to chronic pain hypersensitivity indicates 
      that blocking BDNF in sensory neurons could provide a fruitful strategy for the 
      development of novel analgesics.
FAU - Obata, Koichi
AU  - Obata K
AD  - Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 
      Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
FAU - Noguchi, Koichi
AU  - Noguchi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060303
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Chronic Disease
MH  - Enzyme Activation
MH  - Gene Expression/physiology
MH  - Humans
MH  - Mitogen-Activated Protein Kinase Kinases/metabolism
MH  - Models, Biological
MH  - Neurons, Afferent/*metabolism
MH  - Pain/*metabolism
MH  - Posterior Horn Cells/metabolism
RF  - 129
EDAT- 2006/03/07 09:00
MHDA- 2006/07/14 09:00
CRDT- 2006/03/07 09:00
PHST- 2005/11/11 00:00 [received]
PHST- 2006/01/18 00:00 [revised]
PHST- 2006/01/31 00:00 [accepted]
PHST- 2006/03/07 09:00 [pubmed]
PHST- 2006/07/14 09:00 [medline]
PHST- 2006/03/07 09:00 [entrez]
AID - S0168-0102(06)00024-1 [pii]
AID - 10.1016/j.neures.2006.01.005 [doi]
PST - ppublish
SO  - Neurosci Res. 2006 May;55(1):1-10. doi: 10.1016/j.neures.2006.01.005. Epub 2006 
      Mar 3.