PMID- 16518752
OWN - NLM
STAT- MEDLINE
DCOM- 20060417
LR  - 20061115
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 193
IP  - 7
DP  - 2006 Apr 1
TI  - Down-regulation of human leukocyte antigen class I and II and beta 
      2-microglobulin expression in human herpesvirus-7-infected cells.
PG  - 917-26
AB  - Human herpesvirus (HHV)-7 is a ubiquitous virus that infects >90% of adults. We 
      show that HHV-7 impairs beta2-microglobulin and human leukocyte antigen (HLA) 
      class I and II expression in lymphoid cells in vitro. Accordingly, infected cells 
      were more sensitive to peripheral blood natural cytotoxic activity than were 
      uninfected cells. Analysis of beta2-microglobulin and HLA expression in biopsy 
      specimens from human submandibular glands confirmed the ability of HHV-7 to 
      modulate the expression of these antigens in vivo. We demonstrate that the 
      down-modulation of HLA by HHV-7 is linked to viral replication and is not merely 
      a consequence of the interaction of virions with the cell surface. Infected cells 
      can therefore efficiently escape host immune pressure, which might explain the 
      persistence of HHV-7-positive cells in several kinds of tumors and chronic 
      infectious diseases.
FAU - Mirandola, Prisco
AU  - Mirandola P
AD  - Human Anatomy Section, Department of Anatomy, Pharmacology, and Forensic 
      Medicine, University of Parma, Ospedale Maggiore, Parma, Italy.
FAU - Sponzilli, Ivonne
AU  - Sponzilli I
FAU - Solenghi, Elvira
AU  - Solenghi E
FAU - Micheloni, Cristina
AU  - Micheloni C
FAU - Rinaldi, Laura
AU  - Rinaldi L
FAU - Gobbi, Giuliana
AU  - Gobbi G
FAU - Vitale, Marco
AU  - Vitale M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060224
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antigens, Surface)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Viral Proteins)
RN  - 0 (beta 2-Microglobulin)
SB  - IM
MH  - Antigens, Surface/analysis
MH  - Cell Line
MH  - Flow Cytometry
MH  - Herpesvirus 7, Human/immunology/*physiology
MH  - Histocompatibility Antigens Class I/analysis/*biosynthesis
MH  - Histocompatibility Antigens Class II/*biosynthesis
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphocytes/*immunology/metabolism/*virology
MH  - Submandibular Gland/immunology/virology
MH  - T-Lymphocytes/immunology/metabolism/virology
MH  - Viral Proteins/analysis
MH  - Virus Replication
MH  - beta 2-Microglobulin/analysis/*biosynthesis
EDAT- 2006/03/07 09:00
MHDA- 2006/04/18 09:00
CRDT- 2006/03/07 09:00
PHST- 2005/07/27 00:00 [received]
PHST- 2005/09/26 00:00 [accepted]
PHST- 2006/03/07 09:00 [pubmed]
PHST- 2006/04/18 09:00 [medline]
PHST- 2006/03/07 09:00 [entrez]
AID - JID35379 [pii]
AID - 10.1086/500561 [doi]
PST - ppublish
SO  - J Infect Dis. 2006 Apr 1;193(7):917-26. doi: 10.1086/500561. Epub 2006 Feb 24.