PMID- 16520257
OWN - NLM
STAT- MEDLINE
DCOM- 20060808
LR  - 20161124
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 12
IP  - 2
DP  - 2006 Mar
TI  - Improvement of exercise-induced cardiac deformation after cell therapy for severe 
      chronic ischemic heart failure.
PG  - 108-13
AB  - BACKGROUND: Intracoronary infusion of autologous bone marrow cells (CTX) has been 
      shown to improve myocardial function in postinfarct patients and in patients with 
      chronic ischemic cardiomyopathy. Whether CTX affects exercise-induced changes in 
      cardiac deformation and mitral regurgitation (MR) in patients with end-stage 
      heart failure has not been studied. METHODS AND RESULTS: In this small pilot 
      study, 11 patients with chronic ischemic cardiomyopathy, ejection fraction (EF) 
      <25%, no inducible ischemia and heart failure class New York Heart Association 
      (NYHA) III underwent CTX. Symptom-limited bicycle exercise echocardiography was 
      performed pre- and 4 months post-CTX and maximum systolic strain (msyepsilon), 
      peak systolic strain rate (psysr), and effective regurgitant orifice of MR (ERO) 
      were determined. There were no complications related to the procedure. The 
      overall clinical benefit of CTX was limited with a trend towards improvement 
      (NYHA 3.0 +/- 0.1 pre- and 2.7 +/- 0.2 post-CTX, P = .06). The EF did not improve 
      after CTX. The wall motion score index did not change at rest but decreased 
      significantly during exercise (1.48 +/- 0.16 versus 1.44 +/- 0.17, P = .01). In 
      patients with non-viable areas, msyepsilon, psysr, and ERO were not affected by 
      CTX. However, in patients with viable areas, msyepsilon and psysr appeared to 
      increase during exercise and ERO appeared to decrease from 19 +/- 5 to 16 +/- 5 
      mm(2). This effect was not apparent at rest and more pronounced with inferior 
      viability. CONCLUSION: CTX may improve cardiac deformation and MR during exercise 
      in patients with severe chronic heart failure when viable areas are targeted.
FAU - Lebrun, Frederic
AU  - Lebrun F
AD  - Division of Cardiology, Centre Hospitalier Luxembourg, Centre de Recherche Public 
      Sante, 4 rue Barble, L-1210 Luxembourg.
FAU - Berchem, Guy
AU  - Berchem G
FAU - Delagardelle, Charles
AU  - Delagardelle C
FAU - Beissel, Jean
AU  - Beissel J
FAU - Rouy, Didier
AU  - Rouy D
FAU - Wagner, Daniel R
AU  - Wagner DR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - *Bone Marrow Transplantation
MH  - Echocardiography, Stress
MH  - Female
MH  - Humans
MH  - Infusions, Intra-Arterial
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/diagnostic imaging/physiopathology
MH  - Myocardial Ischemia/diagnostic imaging/physiopathology/*therapy
MH  - Pilot Projects
MH  - Stroke Volume/physiology
MH  - Systole/physiology
MH  - Transplantation, Autologous
MH  - Treatment Outcome
EDAT- 2006/03/08 09:00
MHDA- 2006/08/09 09:00
CRDT- 2006/03/08 09:00
PHST- 2005/07/18 00:00 [received]
PHST- 2005/10/04 00:00 [revised]
PHST- 2005/10/18 00:00 [accepted]
PHST- 2006/03/08 09:00 [pubmed]
PHST- 2006/08/09 09:00 [medline]
PHST- 2006/03/08 09:00 [entrez]
AID - S1071-9164(05)01324-2 [pii]
AID - 10.1016/j.cardfail.2005.10.011 [doi]
PST - ppublish
SO  - J Card Fail. 2006 Mar;12(2):108-13. doi: 10.1016/j.cardfail.2005.10.011.