PMID- 16520413
OWN - NLM
STAT- MEDLINE
DCOM- 20060414
LR  - 20231024
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 113
IP  - 10
DP  - 2006 Mar 14
TI  - Intracoronary bone marrow cell transfer after myocardial infarction: eighteen 
      months' follow-up data from the randomized, controlled BOOST (BOne marrOw 
      transfer to enhance ST-elevation infarct regeneration) trial.
PG  - 1287-94
AB  - BACKGROUND: Intracoronary transfer of autologous bone marrow cells (BMCs) may 
      enhance recovery of left ventricular (LV) function in patients after acute 
      myocardial infarction (AMI). However, clinical studies addressing the effects of 
      BMCs after AMI have covered only limited time frames ranging from 3 to 6 months. 
      The critical question of whether BMC transfer can have a sustained impact on LV 
      function remains unanswered. METHODS AND RESULTS: After percutaneous coronary 
      intervention with stent implantation (PCI) of the infarct-related artery, 60 
      patients were randomized 1:1 to a control group with optimal postinfarction 
      therapy and a BMC transfer group that also received an intracoronary BMC infusion 
      4.8+/-1.3 days after PCI. Cardiac MRI was performed 3.5+/-1.5 days, 6+/-1 months, 
      and 18+/-6 months after PCI. BMC transfer was not associated with adverse 
      clinical events. In the control group, mean global LV ejection fraction increased 
      by 0.7 and 3.1 percentage points after 6 and 18 months, respectively. LV ejection 
      fraction in the BMC transfer group increased by 6.7 and 5.9 percentage points. 
      The difference in LVEF improvement between groups was significant after 6 months 
      but not after 18 months (P=0.27). The speed of LV ejection fraction recovery over 
      the course of 18 months was significantly higher in the BMC transfer group 
      (P=0.001). CONCLUSIONS: In this study, a single dose of intracoronary BMCs did 
      not provide long-term benefit on LV systolic function after AMI compared with a 
      randomized control group; however, the study suggests an acceleration of LV 
      ejection fraction recovery after AMI by BMC therapy.
FAU - Meyer, Gerd P
AU  - Meyer GP
AD  - Department of Cardiology, Hannover Medical School, Hannover, Germany.
FAU - Wollert, Kai C
AU  - Wollert KC
FAU - Lotz, Joachim
AU  - Lotz J
FAU - Steffens, Jan
AU  - Steffens J
FAU - Lippolt, Peter
AU  - Lippolt P
FAU - Fichtner, Stephanie
AU  - Fichtner S
FAU - Hecker, Hartmut
AU  - Hecker H
FAU - Schaefer, Arnd
AU  - Schaefer A
FAU - Arseniev, Lubomir
AU  - Arseniev L
FAU - Hertenstein, Bernd
AU  - Hertenstein B
FAU - Ganser, Arnold
AU  - Ganser A
FAU - Drexler, Helmut
AU  - Drexler H
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20060306
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
CIN - Circulation. 2006 Mar 14;113(10):1272-4. PMID: 16534025
MH  - Adult
MH  - Aged
MH  - Angioplasty, Balloon, Coronary
MH  - Bone Marrow Transplantation/*methods
MH  - *Coronary Vessels
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*therapy
MH  - Stents
MH  - Stroke Volume
MH  - Systole
MH  - Treatment Outcome
MH  - Ventricular Function, Left
EDAT- 2006/03/08 09:00
MHDA- 2006/04/15 09:00
CRDT- 2006/03/08 09:00
PHST- 2006/03/08 09:00 [pubmed]
PHST- 2006/04/15 09:00 [medline]
PHST- 2006/03/08 09:00 [entrez]
AID - CIRCULATIONAHA.105.575118 [pii]
AID - 10.1161/CIRCULATIONAHA.105.575118 [doi]
PST - ppublish
SO  - Circulation. 2006 Mar 14;113(10):1287-94. doi: 10.1161/CIRCULATIONAHA.105.575118. 
      Epub 2006 Mar 6.