PMID- 16520437
OWN - NLM
STAT- MEDLINE
DCOM- 20060329
LR  - 20220330
IS  - 0003-990X (Print)
IS  - 0003-990X (Linking)
VI  - 63
IP  - 3
DP  - 2006 Mar
TI  - Binge-eating disorder as a distinct familial phenotype in obese individuals.
PG  - 313-9
AB  - CONTEXT: Binge-eating disorder (BED)-a syndrome that only recently has attracted 
      scientific attention-is often seen in obese individuals, especially those with 
      severe obesity. However, it remains unclear whether BED represents an 
      etiologically distinct behavioral phenotype of obesity or simply a nonspecific 
      eating pattern sometimes seen in obese individuals. OBJECTIVE: To test whether 
      BED aggregates in families independently of obesity, and if so, whether familial 
      factors for BED also independently increase the risk of obesity. DESIGN, 
      PATIENTS, AND SETTING: Blinded family interview study of overweight or obese 
      probands with (n = 150) and without (n = 150) BED, and their first-degree 
      relatives (n = 888) in a community setting evaluated between October 2002 and 
      July 2004. MAIN OUTCOME MEASURES: Lifetime diagnosis of BED; current and highest 
      lifetime body mass index (calculated as the weight in kilograms divided by the 
      square of the height in meters). RESULTS: Binge-eating disorder aggregated 
      strongly in families independently of obesity (odds ratio, 2.2; 95% confidence 
      interval, 1.4-3.6; P<.001). Furthermore, relatives of probands with BED displayed 
      a markedly higher prevalence of severe obesity in adulthood (body mass index 
      >/=40) than relatives of probands without BED even when controlling for proband 
      body mass index (odds ratio, 2.5; 95% confidence interval, 1.4-4.4; P = .002). 
      CONCLUSIONS: Binge-eating disorder is a familial disorder caused in part by 
      factors distinct from other familial factors for obesity. Furthermore, these 
      BED-specific familial factors may independently increase the risk of obesity, 
      especially severe obesity. It follows that targeted interventions capable of 
      preventing or treating traits influenced by these BED-specific familial factors 
      could reduce the public health burden of obesity.
FAU - Hudson, James I
AU  - Hudson JI
AD  - Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, 
      Mass 02478, USA. jhudson@mclean.harvard.edu
FAU - Lalonde, Justine K
AU  - Lalonde JK
FAU - Berry, Judith M
AU  - Berry JM
FAU - Pindyck, Lindsay J
AU  - Pindyck LJ
FAU - Bulik, Cynthia M
AU  - Bulik CM
FAU - Crow, Scott J
AU  - Crow SJ
FAU - McElroy, Susan L
AU  - McElroy SL
FAU - Laird, Nan M
AU  - Laird NM
FAU - Tsuang, Ming T
AU  - Tsuang MT
FAU - Walsh, B Timothy
AU  - Walsh BT
FAU - Rosenthal, Norman R
AU  - Rosenthal NR
FAU - Pope, Harrison G Jr
AU  - Pope HG Jr
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Gen Psychiatry
JT  - Archives of general psychiatry
JID - 0372435
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Bulimia Nervosa/*epidemiology/*genetics
MH  - Comorbidity
MH  - Cost of Illness
MH  - *Family
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*epidemiology/*genetics
MH  - Pedigree
MH  - *Phenotype
MH  - Prevalence
MH  - Risk Factors
MH  - Social Environment
EDAT- 2006/03/08 09:00
MHDA- 2006/03/30 09:00
CRDT- 2006/03/08 09:00
PHST- 2006/03/08 09:00 [pubmed]
PHST- 2006/03/30 09:00 [medline]
PHST- 2006/03/08 09:00 [entrez]
AID - 63/3/313 [pii]
AID - 10.1001/archpsyc.63.3.313 [doi]
PST - ppublish
SO  - Arch Gen Psychiatry. 2006 Mar;63(3):313-9. doi: 10.1001/archpsyc.63.3.313.