PMID- 16522229
OWN - NLM
STAT- MEDLINE
DCOM- 20060602
LR  - 20061115
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 8
IP  - 1
DP  - 2006 Feb
TI  - [Correlation of serum IL-16, IL-18 levels and immunoglobulins in children with 
      asthma].
PG  - 6-8
AB  - OBJECTIVE: This study examined the changes of serum levels of interleukin 
      (IL)-16, IL-18 and immunoglobulins and the correlation of serum IL-16, IL-18 
      levels and immunoglobulins in children with asthma and aimed to explore the role 
      of IL-16, IL-18 and immunoglobulins in the pathogenesis of asthma. METHODS: 
      Thirty-four children with asthma and 21 age and gender-matched healthy children 
      were enrolled in this study. The levels of IL-16, IL-18 and immunoglobulin E 
      (IgE) were determined using ELISA. Immunoglobulin G (IgG), immunoglobulin M (IgM) 
      and immunoglobulin A (IgA) were detected by immunoturbidimetry. RESULTS: The 
      levels of IL-16, IL-18 and IgE in patients with asthma at both acute attack and 
      convalescence stages were significantly higher than those in healthy controls. An 
      increased IgG and a decreased IgA levels were found in asthmatic patients at the 
      acute attack stage. There was a positive correlation between the IL-16 and IL-18 
      levels at both acute attack and convalescence stages of asthma (r=0.70, P < 0.01; 
      r=0.70, P < 0.05). The IL-16 level correlated positively with the IgE level at 
      acute attack stage of asthma (r=0.624, P < 0.01). CONCLUSIONS: IL-16, IL-18 and 
      IgE may be involved in the pathogenesis of asthma. The immunologic imbalance 
      exists in children with asthma at both acute attack and convalescence stages. 
      Anti-allergic therapy should be administered through the acute attack to the 
      convalescence stages of asthma.
FAU - Xue, Yi-Nan
AU  - Xue YN
AD  - Department of Pediatrics, Changsha Center Hospital, Changsha 410007, China. 
      xyn63@yahoo.com.cn
FAU - Zou, Xian-De
AU  - Zou XD
FAU - Wu, Jia-Ling
AU  - Wu JL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
RN  - 0 (Immunoglobulins)
RN  - 0 (Interleukin-16)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adolescent
MH  - Asthma/etiology/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunoglobulins/*blood
MH  - Interleukin-16/*blood
MH  - Interleukin-18/*blood
MH  - Male
EDAT- 2006/03/09 09:00
MHDA- 2006/06/03 09:00
CRDT- 2006/03/09 09:00
PHST- 2006/03/09 09:00 [pubmed]
PHST- 2006/06/03 09:00 [medline]
PHST- 2006/03/09 09:00 [entrez]
AID - 1008-8830(2006)01-0006-03 [pii]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2006 Feb;8(1):6-8.