PMID- 16522457
OWN - NLM
STAT- MEDLINE
DCOM- 20060613
LR  - 20061115
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 117
IP  - 3
DP  - 2006 Mar
TI  - Neurotrophins in allergic diseases: from neuronal growth factors to intercellular 
      signaling molecules.
PG  - 583-9
AB  - Understanding the complex pathophysiology of allergic diseases has been a main 
      challenge of clinical and experimental research for many years. It is well known 
      that the allergic inflammation triggers neuronal dysfunction and structural 
      changes in the diseased tissues such as the airways or the skin. Recent evidence 
      has emerged that the inflammatory response is also controlled by resident tissue 
      cells such as neurons and structural cells. Therefore, signaling molecules that 
      mediate inflammatory interactions among immune, neuronal, and structural cells 
      are becoming a focus of allergy research. Neurotrophins, a family of homologous 
      growth factors initially discovered in the nervous system, display such 
      bidirectional signaling. The expression of neurotrophins, such as nerve growth 
      factor (NGF) and brain-derived neurotrophic factor (BDNF), is highly upregulated 
      during allergic inflammation. Neurons, structural cells, and invading immune 
      cells were now identified not only as sources but also as targets of 
      neurotrophins within the inflamed tissue. In this review, we provide an actual 
      overview of the role of neurotrophins in the pathobiology of allergic diseases. 
      We discuss recent findings in human and animal studies such as the regulation of 
      neurotrophin expression during allergic inflammation and the effect of 
      neurotrophins on the development and magnitude of allergic reactions.
FAU - Nockher, Wolfgang Andreas
AU  - Nockher WA
AD  - Department of Clinical Chemistry and Molecular Diagnostics, University Hospital, 
      Philipps-Universitat Marburg, Germany. nockher@med.uni-marburg.de
FAU - Renz, Harald
AU  - Renz H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/immunology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Nerve Growth Factor/immunology
MH  - Nerve Growth Factors/immunology/*physiology
MH  - Receptors, Nerve Growth Factor/immunology
MH  - Signal Transduction
RF  - 66
EDAT- 2006/03/09 09:00
MHDA- 2006/06/14 09:00
CRDT- 2006/03/09 09:00
PHST- 2005/08/22 00:00 [received]
PHST- 2005/11/04 00:00 [revised]
PHST- 2005/11/09 00:00 [accepted]
PHST- 2006/03/09 09:00 [pubmed]
PHST- 2006/06/14 09:00 [medline]
PHST- 2006/03/09 09:00 [entrez]
AID - S0091-6749(06)00306-X [pii]
AID - 10.1016/j.jaci.2005.11.049 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2006 Mar;117(3):583-9. doi: 10.1016/j.jaci.2005.11.049.