PMID- 16522641
OWN - NLM
STAT- MEDLINE
DCOM- 20060628
LR  - 20231213
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 281
IP  - 18
DP  - 2006 May 5
TI  - Chronic antidepressants potentiate via sigma-1 receptors the brain-derived 
      neurotrophic factor-induced signaling for glutamate release.
PG  - 12941-9
AB  - Up-regulation of BDNF (brain-derived neurotrophic factor) has been suggested to 
      contribute to the action of antidepressants. However, it is unclear whether 
      chronic treatment with antidepressants may influence acute BDNF signaling in 
      central nervous system neurons. Because BDNF has been shown by us to reinforce 
      excitatory glutamatergic transmission in cultured cortical neurons via the 
      phospholipase-gamma (PLC-gamma)/inositol 1,4,5-trisphosphate (IP3)/Ca2+ pathway 
      (Numakawa, T., Yamagishi, S., Adachi, N., Matsumoto, T., Yokomaku, D., Yamada, 
      M., and Hatanaka, H. (2002) J. Biol. Chem. 277, 6520-6529), we examined in this 
      study the possible effects of pretreatment with antidepressants on the BDNF 
      signaling through the PLC-gamma)/IP3/Ca2+ pathway. Furthermore, because the 
      PLC-gamma/IP3/Ca2+ pathway is regulated by sigma-1 receptors (Hayashi, T., and 
      Su, T. P. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 491-496), we examined 
      whether the BDNF signaling is modulated by sigma-1 receptors (Sig-1R). We found 
      that the BDNF-stimulated PLC-gamma activation and the ensued increase in 
      intracellular Ca2+ ([Ca2+]i) were potentiated by pretreatment with imipramine or 
      fluvoxamine, so was the BDNF-induced glutamate release. Furthermore, enhancement 
      of the interaction between PLC-gamma and TrkB (receptor for BDNF) after 
      imipramine pretreatment was observed. Interestingly, BD1047, a potent Sig-1R 
      antagonist, blocked the imipramine-dependent potentiation on the BDNF-induced 
      PLC-gamma activation and glutamate release. In contrast, overexpression of Sig-1R 
      per se, without antidepressant pretreatment, enhances BDNF-induced PLC-gamma 
      activation and glutamate release. These results suggest that antidepressant 
      pretreatment selectively enhance the BDNF signaling on the PLC-gamma/IP3/Ca2+ 
      pathway via Sig-1R, and that Sig-1R plays an important role in BDNF signaling 
      leading to glutamate release.
FAU - Yagasaki, Yuki
AU  - Yagasaki Y
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo 187-8502, Japan.
FAU - Numakawa, Tadahiro
AU  - Numakawa T
FAU - Kumamaru, Emi
AU  - Kumamaru E
FAU - Hayashi, Teruo
AU  - Hayashi T
FAU - Su, Tsung-Ping
AU  - Su TP
FAU - Kunugi, Hiroshi
AU  - Kunugi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060306
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antidepressive Agents, Second-Generation)
RN  - 0 (Antidepressive Agents, Tricyclic)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Calcium Channels)
RN  - 0 (Inositol 1,4,5-Trisphosphate Receptors)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, sigma)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - O4L1XPO44W (Fluvoxamine)
RN  - OGG85SX4E4 (Imipramine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Antidepressive Agents, Second-Generation/pharmacology
MH  - Antidepressive Agents, Tricyclic/pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Calcium Channels/metabolism
MH  - Fluvoxamine/pharmacology
MH  - Glutamic Acid/*metabolism
MH  - Imipramine/pharmacology
MH  - Inositol 1,4,5-Trisphosphate Receptors
MH  - Neurons/drug effects/metabolism
MH  - Neurotransmitter Agents/metabolism
MH  - Rats
MH  - Receptors, Cytoplasmic and Nuclear/metabolism
MH  - Receptors, sigma/*metabolism
MH  - Signal Transduction
MH  - Sigma-1 Receptor
EDAT- 2006/03/09 09:00
MHDA- 2006/06/29 09:00
CRDT- 2006/03/09 09:00
PHST- 2006/03/09 09:00 [pubmed]
PHST- 2006/06/29 09:00 [medline]
PHST- 2006/03/09 09:00 [entrez]
AID - S0021-9258(19)46629-5 [pii]
AID - 10.1074/jbc.M508157200 [doi]
PST - ppublish
SO  - J Biol Chem. 2006 May 5;281(18):12941-9. doi: 10.1074/jbc.M508157200. Epub 2006 
      Mar 6.