PMID- 16523260
OWN - NLM
STAT- MEDLINE
DCOM- 20070104
LR  - 20181113
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 449
IP  - 3
DP  - 2006 Sep
TI  - Anatomic site-specific patterns of gene copy number gains in skin, mucosal, and 
      uveal melanomas detected by fluorescence in situ hybridization.
PG  - 328-33
AB  - To assess the differences between melanomas of different location and different 
      etiology, 372 malignant melanomas were brought in a tissue microarray format. The 
      collection included 23 acral and 118 non-acral skin melanomas, 9 mucosal 
      melanomas, 100 uveal melanomas, and 122 melanoma metastases. Fluorescence in situ 
      hybridization (FISH) was used to assess copy number changes of the cyclin D1 
      (CCND1), MDM2, c-myc (MYC), and HER2 genes. FISH analysis revealed distinct 
      differences between melanomas from different locations. CCND1 amplifications were 
      detected in skin melanomas from sites with chronic sun exposure (6 of 32 cases), 
      acral melanomas (4 of 17 cases), and mucosal melanomas (one of ten cases) but not 
      in uveal melanomas. High-level MDM2 amplifications were exclusively present in 
      acral melanomas (2 of 19 cases). MYC copy number gains were detected in 32 of 71 
      uveal melanomas, five of eight mucosal melanomas, and 6 of 67 melanomas from 
      sites with intermittent sun exposure but not in acral melanomas nor melanomas 
      from sites with chronic sun exposure. Alterations of the MYC gene were associated 
      with advanced tumor stage. There were no high-level HER2 amplifications. 
      Site-specific genetic and epigenetic features may impact the response of 
      melanomas to various anti-cancer drugs and should be considered in future studies 
      on the molecular pathogenesis of malignant melanomas.
FAU - Glatz-Krieger, Katharina
AU  - Glatz-Krieger K
AD  - Institute for Pathology, University of Basel, Schoenbeinstrasse 40, CH-4031, 
      Basel, Switzerland. Katharina.Glatz@unibas.ch
FAU - Pache, Mona
AU  - Pache M
FAU - Tapia, Coya
AU  - Tapia C
FAU - Fuchs, Alain
AU  - Fuchs A
FAU - Savic, Spasenija
AU  - Savic S
FAU - Glatz, Dieter
AU  - Glatz D
FAU - Mihatsch, Michael
AU  - Mihatsch M
FAU - Meyer, Peter
AU  - Meyer P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060308
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - DNA, Neoplasm/analysis
MH  - Gene Amplification
MH  - *Gene Dosage
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Lymph Nodes/pathology
MH  - Melanoma/*genetics/metabolism/secondary
MH  - Mucous Membrane/metabolism/*pathology
MH  - Skin Neoplasms/*genetics/metabolism/pathology
MH  - Tissue Array Analysis
MH  - Uveal Neoplasms/*genetics/metabolism/pathology
EDAT- 2006/03/09 09:00
MHDA- 2007/01/05 09:00
CRDT- 2006/03/09 09:00
PHST- 2005/12/21 00:00 [received]
PHST- 2006/01/25 00:00 [accepted]
PHST- 2006/03/09 09:00 [pubmed]
PHST- 2007/01/05 09:00 [medline]
PHST- 2006/03/09 09:00 [entrez]
AID - 10.1007/s00428-006-0167-8 [doi]
PST - ppublish
SO  - Virchows Arch. 2006 Sep;449(3):328-33. doi: 10.1007/s00428-006-0167-8. Epub 2006 
      Mar 8.