PMID- 1652350
OWN - NLM
STAT- MEDLINE
DCOM- 19910927
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 68
IP  - 6 Suppl
DP  - 1991 Sep 15
TI  - Intravenous immunoglobulin in bone marrow transplantation.
PG  - 1451-3
AB  - Intravenous immunoglobulin (IVIG) has several potential uses in bone marrow 
      transplantation. Most often IVIG is used to modify cytomegalovirus (CMV) 
      infection or CMV-related interstitial pneumonia. It also is used to modify graft 
      versus host disease (GVHD) and decrease infections other than CMV. Another use is 
      to treat autoimmune complications of bone marrow transplants. The data are 
      reviewed indicating that IVIG decreases CMV-related interstitial pneumonia. Part 
      of this efficacy may be a direct antiviral effect; decreasing GVHD and modifying 
      the immune response to CMV-infected lung cells also may be important. Some 
      studies suggest that IVIG and ganciclovir are effective therapy of CMV-related 
      interstitial pneumonia. Results suggesting that IVIG administration decreases 
      infections other than CMV are less convincing. There is little information 
      regarding IVIG therapy of autoimmune transplant complications. These uses of IVIG 
      are reviewed in the context of other potential interventions, and future research 
      directions are defined.
FAU - Gale, R P
AU  - Gale RP
AD  - Department of Medicine, University of California Los Angeles School of Medicine 
      90024-1678.
FAU - Winston, D
AU  - Winston D
LA  - eng
GR  - CA 38569/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Cytomegalovirus Infections/*prevention & control
MH  - Graft vs Host Disease/prevention & control
MH  - Humans
MH  - *Immunization, Passive/trends
MH  - Infection Control
MH  - Pulmonary Fibrosis/*prevention & control
RF  - 16
EDAT- 1991/09/15 00:00
MHDA- 1991/09/15 00:01
CRDT- 1991/09/15 00:00
PHST- 1991/09/15 00:00 [pubmed]
PHST- 1991/09/15 00:01 [medline]
PHST- 1991/09/15 00:00 [entrez]
AID - 10.1002/1097-0142(19910915)68:6+<1451::aid-cncr2820681408>3.0.co;2-r [doi]
PST - ppublish
SO  - Cancer. 1991 Sep 15;68(6 Suppl):1451-3. doi: 
      10.1002/1097-0142(19910915)68:6+<1451::aid-cncr2820681408>3.0.co;2-r.