PMID- 16524060
OWN - NLM
STAT- MEDLINE
DCOM- 20060503
LR  - 20211203
IS  - 0034-8376 (Print)
IS  - 0034-8376 (Linking)
VI  - 57
IP  - 2
DP  - 2005 Mar-Apr
TI  - [The highly sensitized patient. Therapeutic alternatives for kidney 
      transplantation].
PG  - 206-12
AB  - Patients become sensitized after exposure to non-self human leukocyte antigen 
      (HLA) during pregnancy, blood transfusion, and organ transplantation. Performing 
      transplantation in highly sensitized receptors represents a challenge for 
      transplant programs, organ allocation organizations and usually patients are 
      forced to stay on transplant waiting lists for many years and ultimately may 
      never find a donor. There are various approaches that can be adopted in order to 
      transplant these patients such as plasmapheresis, immunoadsorption, intravenous 
      immune globulin, anti-thymocyte agents, monoclonal antibodies (anti CD-20) and 
      splenectomy with similar results as obtained in non highly sensitized patients 
      with the increased risk of severe and recurrent rejection which may carry 
      implications for long-term graft outcomes. Thus a positive crossmatch test is not 
      necessarily an absolute contraindication and allows access for transplantation.
FAU - Mancilla-Urrea, Eduardo
AU  - Mancilla-Urrea E
AD  - Departamento de Nefrologia del Instituto Nacional de Cardiologia Ignacio Chavez, 
      Mexico, DF. emulmps@mexis.com
LA  - spa
PT  - Journal Article
PT  - Review
TT  - El paciente altamente sensibilizado. Alternativas terapeuticas para el trasplante 
      renal.
PL  - Mexico
TA  - Rev Invest Clin
JT  - Revista de investigacion clinica; organo del Hospital de Enfermedades de la 
      Nutricion
JID - 9421552
RN  - 0 (Antilymphocyte Serum)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Antilymphocyte Serum/therapeutic use
MH  - Histocompatibility
MH  - Humans
MH  - *Immunization
MH  - Immunoglobulins, Intravenous/administration & dosage/therapeutic use
MH  - Immunosorbent Techniques
MH  - Immunosuppression Therapy/*methods
MH  - Isoantibodies/immunology
MH  - Kidney Transplantation/*immunology
MH  - Plasmapheresis
MH  - Splenectomy
MH  - T-Lymphocyte Subsets/immunology
RF  - 54
EDAT- 2006/03/10 09:00
MHDA- 2006/05/04 09:00
CRDT- 2006/03/10 09:00
PHST- 2006/03/10 09:00 [pubmed]
PHST- 2006/05/04 09:00 [medline]
PHST- 2006/03/10 09:00 [entrez]
PST - ppublish
SO  - Rev Invest Clin. 2005 Mar-Apr;57(2):206-12.