PMID- 1652618
OWN - NLM
STAT- MEDLINE
DCOM- 19910927
LR  - 20190827
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 33
IP  - 3
DP  - 1991 Mar
TI  - A serological investigation of human herpesvirus 6 infections in liver transplant 
      recipients and the detection of cross-reacting antibodies to cytomegalovirus.
PG  - 172-6
AB  - Sera from 50 orthotopic liver transplant recipients were examined for antibodies 
      to human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV), and the findings 
      correlated with the clinical condition of the patients. Both primary and 
      secondary HHV-6 infections were detected serologically following liver 
      transplantation. Interpretation of serological assays is complicated by CMV and 
      HHV-6 antibody cross reactions which were common. Sera from 5 patients became 
      HHV-6 antibody negative following absorption with CMV infected cells. Thirty 
      patients were initially seronegative for HHV-6 antibodies, 12 remained so 
      following transplantation, 5 developed cross reacting antibodies, and 13 
      seroconverted. The seroconversions occurred at 4 to 8 weeks post-transplant in 
      the same time period as CMV antibody rises. HHV-6 IgM was detected in only 4 of 
      the 13. Of the 7 patients who had serological evidence of active HHV-6 infections 
      but no evidence of CMV infection, 4 (56%) had fever, 1 (14%) hepatitis, 1 (14%) 
      lung dysfunction, and 3 (42%) neurological disorders. In the 12 patients who 
      remained HHV-6 antibody negative, there were fewer fevers and neurological 
      disorders.
FAU - Sutherland, S
AU  - Sutherland S
AD  - Virology Section, Public Health Laboratory, Dulwich Hospital, London, England.
FAU - Christofinis, G
AU  - Christofinis G
FAU - O'Grady, J
AU  - O'Grady J
FAU - Williams, R
AU  - Williams R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Antibodies, Viral/*analysis/immunology
MH  - Cell Line
MH  - Cross Reactions
MH  - Cytomegalovirus/*immunology
MH  - Herpesviridae Infections/etiology/*microbiology
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - *Liver Transplantation/adverse effects
MH  - Retrospective Studies
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
AID - 10.1002/jmv.1890330306 [doi]
PST - ppublish
SO  - J Med Virol. 1991 Mar;33(3):172-6. doi: 10.1002/jmv.1890330306.