PMID- 16527694
OWN - NLM
STAT- MEDLINE
DCOM- 20060606
LR  - 20111117
IS  - 1542-3565 (Print)
IS  - 1542-3565 (Linking)
VI  - 4
IP  - 3
DP  - 2006 Mar
TI  - Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac 
      disease and enteropathy-associated T-cell lymphoma.
PG  - 315-9
AB  - BACKGROUND & AIMS: Celiac disease (CD) is a common gluten-sensitive enteropathy 
      associated with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. The aim of this 
      study was to determine if a particular HLA-DQ subtype predisposes to 
      complications such as refractory CD with (RCD II) or without aberrant T cells 
      (RCD I), and enteropathy-associated T-cell lymphomas (EATL). METHODS: Molecular 
      HLA-DQ typing was performed on 43 RCD I, 43 RCD II, and 30 EATL patients, and 
      compared with age-matched groups of 121 patients with histologically defined 
      uncomplicated CD and 183 healthy controls. All individuals were Dutch Caucasians 
      and were at least 21 years of age. RESULTS: HLA-DQ2 was present in 79% of RCD I, 
      97.7% of RCD II, and 96.6% of EATL patients. The differences were significant 
      when compared with 28.9% in controls but not with 91.7% in uncomplicated CD. 
      Homozygosity for HLA-DQ2 was observed in 25.5% of RCD I, 44.1% of RCD II, and 
      53.3% of EATL patients vs 20.7% of uncomplicated CD patients and 2.1% of 
      controls. HLA-DQ8 was present in 10.7% of CD, 16.2% of RCD I, 9.3% of RCD II, and 
      6.6% of EATL patients vs 20.2% of controls. CONCLUSIONS: Homozygosity for HLA-DQ2 
      is associated with RCD II and EATL. Early identification of HLA-DQ2 homozygous CD 
      patients may help to recognize CD patients at risk for developing these severe 
      complications.
FAU - Al-Toma, Abdulbaqi
AU  - Al-Toma A
AD  - Department of Gastroenterology, VU University Medical Center, Amsterdam, The 
      Netherlands.
FAU - Goerres, Marije S
AU  - Goerres MS
FAU - Meijer, Jos W R
AU  - Meijer JW
FAU - Pena, A Salvador
AU  - Pena AS
FAU - Crusius, J Bart A
AU  - Crusius JB
FAU - Mulder, Chris J J
AU  - Mulder CJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Gastroenterol Hepatol
JT  - Clinical gastroenterology and hepatology : the official clinical practice journal 
      of the American Gastroenterological Association
JID - 101160775
RN  - 0 (Antigens, CD)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD/metabolism
MH  - Case-Control Studies
MH  - Celiac Disease/*genetics/metabolism/pathology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - *Homozygote
MH  - Humans
MH  - Lymphoma, T-Cell/*genetics/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Receptors, Antigen, T-Cell/metabolism
EDAT- 2006/03/11 09:00
MHDA- 2006/06/07 09:00
CRDT- 2006/03/11 09:00
PHST- 2006/03/11 09:00 [pubmed]
PHST- 2006/06/07 09:00 [medline]
PHST- 2006/03/11 09:00 [entrez]
AID - S1542-3565(05)01182-1 [pii]
AID - 10.1016/j.cgh.2005.12.011 [doi]
PST - ppublish
SO  - Clin Gastroenterol Hepatol. 2006 Mar;4(3):315-9. doi: 10.1016/j.cgh.2005.12.011.